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GHK-Cu navorsingspeptied

Navorsingsoorsig

GHK-Cu

Koper-tripeptied · matriks en geenuitdrukking

Janoshik HPLC-suiwerheidSertifikaat van AnaliseSlegs vir navorsingsdoeleindes

IN SESTIG SEKONDES

  • • Kom natuurlik voor; die plasmakonsentrasie daal met ouderdom.
  • • Die mees bestelde verbinding in ons katalogus.
  • • Beskikbaar in 50 mg en 100 mg.

MEGANISME

GHK-Cu is die koper(II)-kompleks van die tripeptied glisiel-L-histidiel-L-lisien, in 1973 in menslike plasma geïdentifiseer. Die vrye peptied bind koper met ’n hoë affiniteit en dien in laboratoriummodelle as koperdraer na selle en ensieme wat koper benodig.

Die grootste deel van die literatuur handel oor die ekstrasellulêre matriks: in fibroblast- en huidmodelle word GHK-Cu geassosieer met die uitdrukking van kollageen, elastien, dekorien en metalloproteïnase-inhibitore. Geenuitdrukking-studies rapporteer dat dit die aktiwiteit van ’n groot aantal menslike gene in selkulture verander.

WAT DIE LITERATUUR DEK

  • Koperbinding en -vervoer in selmodelle
  • Kollageen- en elastiensintese in fibroblastkulture
  • Breëspektrum geenuitdrukking-profiele (Broad Institute-data)
  • Velmodelle: wondmatriks, hare-follikel-studies in diere

GEDOKUMENTEERDE NAVORSINGSAREAS

  • Koperkompleks van die tripeptied glisiel-L-histidiel-L-lisien
  • Kom natuurlik in menslike plasma voor; die konsentrasie daal met ouderdom
  • Bestudeer as koperdraer en moduleerder van geenuitdrukking
  • Aangehaal in kollageen-, elastien- en ekstrasellulêre-matriksnavorsing
  • 50 mg gevriesdroogde flessie, suiwerheid deur ’n derde party getoets
  • Verskaf slegs vir laboratoriumnavorsing

AANGEHAALDE STUDIES

Titels en bevindinge in Engels, soos gepubliseer.

  1. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

    Biomed Res Int · 2015 · PMID 26236730

    A review describing GHK modulation of multiple gene-expression and signalling pathways involved in skin regeneration.

  2. GHK and DNA: resetting the human genome to health

    Biomed Res Int · 2014 · PMID 25302294

    An analysis of gene-expression datasets reporting that GHK can shift transcription of many genes toward a more youthful profile in vitro.

  3. Expression and activation of matrix metalloproteinases in wounds: modulation by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+

    J Invest Dermatol · 1999 · PMID 10383745

    In experimental wounds, the GHK-copper complex modulated expression and activation of matrix metalloproteinases involved in tissue remodelling.

  4. Effect of tripeptide-copper complexes on the process of skin wound healing and on cultured fibroblasts

    Arch Int Pharmacodyn Ther · 1995 · PMID 8836453

    Copper-tripeptide complexes influenced skin wound-healing processes and cultured-fibroblast behaviour in animal and cell studies.

  5. The human tri-peptide GHK and tissue remodeling

    J Biomater Sci Polym Ed · 2008 · PMID 18644225

    A review of the human tripeptide GHK and its reported roles in tissue remodelling and matrix regulation.

Volledige navorsingsoorsig met literatuurpaneel (in Engels) →·Bekyk alle produkte

Alle produkte word uitsluitlik vir laboratorium- en wetenskaplike navorsing verskaf — nie vir menslike of veeartsenykundige gebruik nie, en nie vir die diagnose of behandeling van enige toestand nie. Living Water Labs is nie ’n apteek nie en maak geen mediese of terapeutiese aansprake oor enige produk nie.

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