MOTS-cLongevity
Metabolic8/10
- Metabolic8
- Satiety2
- Body Comp7
- Repair6
- Skin & Hair3
- Gut & Immune4
- Cognition4
- Mood4
- Sleep4
- Longevity9
Pre-order · save 10% · ships 15 Oct
MOTS-c 40mg
Mitochondrial Open Reading Frame of the 12S rRNA-c
Mitochondrial-derived 16-amino-acid peptide, 40 mg lyophilised powder per vial.
R1 484R1 649Pre-order −10%
Earn R74 in points · 5% back as store credit
Supply40 wks
BAC3 ml incl.
Quantity
1
Dispatch15-OctPre-order now and save 10% — new stock lands 15 Oct
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7 researchers waiting
Delivery estimate
See your dispatch day and arrival dates before you order.
Same R130 courier anywhere in SA · free over R2,500 · PUDO lockers R130.
Quality passport
MOTS-c 40mg
Independently tested by Janoshik Analytical
- Purity
- 99.229%HPLC
- Tested by
- JanoshikIndependent lab
- Batch
- 2026626
- Certificate
- PublishedBatch summary
- Form
- LyophilisedSealed vial
- Net content
- 40 mg
- Per mg
- R41.2R1.67/mg less than the 10 mg
- Stocked in
- South AfricaNo customs wait
- Dispatch
- On restockNotify-me above
- Supplied for
- Research useNot for human use
LWL-MOTS-C · 2026626
Where the literature concentrates
Research profile
MOTS-c
Metabolic
Published research on metabolic
MOTS-c. Activates AMPK to stimulate robust fatty acid oxidation and reverse diet-induced insulin resistance.
Scores summarise published research, most of it laboratory and animal work. They describe what has been studied, not results in people. For research use only.
Evidence profile
Preliminary- Human clinical
- Human observational
- Animal models
- Cell / in vitro
- Mechanistic
Mostly animal and cell work, with human association studies; controlled human trials are limited.
Grades describe how much of each kind of research exists, not what a compound does. Conservative by design.
Cited findings
Mitochondrial origin
A 16-amino-acid peptide from a short open reading frame in the mitochondrial 12S rRNA; it improved insulin sensitivity and metabolic homeostasis in mice.
Physical capacity, any age
Enhanced physical performance in young, middle-aged and old mice; late-life treatment increased physical capacity and healthspan.
Exercise-induced in humans
In humans, exercise raised MOTS-c in skeletal muscle and in circulation.
Human + mouseNat Commun 2021 · PMID 33473109 ↗Muscle-targeted
Its primary target organ appears to be skeletal muscle, where it acts through the folate cycle and AMPK.
Mito-to-nucleus signal
Reviewed as a mitochondrial signal that regulates muscle and fat metabolism.
Key literature
Human research
Cell & mechanism
- MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitationA 2023 review summarising MOTS-c biology and its potential as a research target in metabolic and age-related conditions.PMID 36761202 ↗
- Mitochondrial-derived peptides and exerciseA review examining how exercise influences mitochondrial-derived peptides including MOTS-c.PMID 34520826 ↗
What MOTS-c is
A peptide encoded in mitochondrial DNA itself — discovered at USC and shown in Cell Metabolism to activate AMPK and restore metabolic balance in mice.
Each vial contains 40mg of lyophilised MOTS-c, supplied as a sterile powder for reconstitution. MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a 16-amino-acid mitochondrial-derived peptide encoded within the 12S rRNA gene. Discovered in 2015 by researchers at USC, MOTS-c has rapidly emerged as a key metabolic regulator and exercise mimetic. It activates AMPK and targets the folate cycle and de novo purine synthesis, redirecting cellular metabolism toward fat oxidation. Animal studies show that MOTS-c administration prevents high-fat-diet-induced obesity, reverses insulin resistance, and extends lifespan in aging mice. Its plasma levels decline with age, suggesting a role in age-related metabolic decline. Exercise increases circulating MOTS-c, and exogenous administration replicates many exercise-induced metabolic adaptations — making it a compelling subject for metabolic disease and longevity research.
Mechanism, as studied
MOTS-c lets mitochondria talk to the rest of the cell — sensing metabolic stress and switching on the cell’s energy sensor.
- STEP 01Translated from a short reading frame inside mitochondrial 12S rRNA
- STEP 02Inhibits the folate cycle and tethered de novo purine synthesis
- STEP 03The metabolic shift activates AMPK, the cell’s energy sensor
- STEP 04Regulates nuclear genes for metabolism and stress adaptation
Also known as
MOTS-cMitochondrial Peptide12S rRNA-c Peptide
Product specification
| Product | MOTS-c |
|---|---|
| Identity | Mitochondrial Open Reading Frame of the 12S rRNA-c |
| Size | 40 mg |
| Form | Lyophilised powder, sealed vial |
| Purity | 99.229%HPLC, per batch |
| Mol. weight | 2174.6 g/mol |
| Batch | 2026626 |
| Price per mg | R41.2 / mgR1.67/mg less than the 10 mg |
| Supply | Up to 10 WeeksTypical research schedule |
| Included | 3 ml bacteriostatic water |
| Storage | Store at −20 °C in a dry, sealed environmentReconstitute with bacteriostatic water; use within 30 days at 4 °C · Avoid repeated freeze–thaw cycles |
| Supplied for | Laboratory research onlyNot for human or veterinary use |
What arrives in your box
Six things, every order
Packed in South Africa, dispatched on business days, tracked to your door.
- Your research compound
Sealed, lyophilised vial, exactly as listed: compound and strength on the label.
- Batch identification
The batch number printed on the vial ties it to its certificate.
- Certificate access
Janoshik Analytical batch summary, viewable online.
- BAC water included
One 3 ml bacteriostatic water vial per peptide vial, at no charge.
- Protective packaging
Padded, discreet outer box. No product names on the outside.
- Courier tracking
The Courier Guy waybill is emailed the day it leaves us.
For laboratory research use only. Not for human or veterinary use.
Tested by Janoshik
Certificate of analysis
Each certificate is an independent Janoshik Analytical report naming the compound and its HPLC purity. Certificates we have not yet published are available on request.
| Assay | MOTS-c · HPLC |
|---|---|
| Purity | 99.229% |
| Batch | 2026626 |
| Mol. weight | 2174.6 g/mol |
Before you order
01What purity standard do your peptides meet?
Quality is documented by independent Janoshik Analytical reports (compound identity and HPLC purity) linked from each product page, with unpublished certificates available on request. Each Certificate of Analysis names the compound and reports its HPLC purity; published certificates are at livingwaterlabs.co.za/verify and any other is sent on request.
02Do you provide Certificates of Analysis?
Yes. Our certificates are independent Janoshik Analytical reports naming the compound and its HPLC purity. Published certificates are readable at livingwaterlabs.co.za/verify; for a compound not yet listed there, ask us on WhatsApp and we send it before you order.
03How should research peptides be stored upon receipt?
Peptides should be stored at -20°C in a sealed, dry environment. Once reconstituted, solutions should be stored at 4°C and used within 30 days, or aliquoted and stored at -80°C for longer-term stability. Avoid repeated freeze-thaw cycles.
04How long does delivery take in South Africa?
Orders are packed and dispatched within 1–2 business days and delivered door-to-door by tracked courier anywhere in South Africa. A tracking number is emailed to you when the courier collects. Standard courier is R130.
05What payment methods do you accept?
We accept EFT bank transfer. Banking details are provided at checkout. Please use your order reference number as payment reference so your order can be processed promptly.
06What does "for research purposes only" mean?
It means every product supplied by Living Water Labs is sold as a research chemical for laboratory and scientific investigation only, and is not supplied for human or veterinary use, not for the diagnosis or treatment of any condition, and not as a food, cosmetic or medicine. Living Water Labs is not a pharmacy, makes no medical or therapeutic claims about any product, and does not provide human dosing, treatment protocols, diagnosis or disease recommendations. What we do provide — identity, purity, certificates, literature, molecular data, reconstitution maths, handling and storage — is listed at livingwaterlabs.co.za/faq#research-use. Buyers confirm legitimate research intent at the point of order.
Research support
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- Whether you are new to research peptides
WhatsApp us 076 680 0306Or WhatsApp 072 926 7667
Mon–Fri · 9:00–17:00 SAST · catalogue & documentation help, never dosing advice
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