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MOTS-c research peptide

Research Overview

MOTS-c

Energy & Easy Fat Loss

HPLC-verified 98%Batch CoAResearch use only

OVERVIEW

MOTS-c (Energy & Easy Fat Loss) is a research-grade peptide supplied by Living Water Labs for laboratory investigation. Cellular energy peptide that sharpens insulin sensitivity and metabolism. Each batch is HPLC-verified to a minimum 98% purity with a batch-specific Certificate of Analysis. The summary below outlines documented mechanisms and study areas reported in the research literature.

Scientific name

Mitochondrial Open Reading Frame of the 12S rRNA-c

Molecular weight

2174.6 g/mol

Purity

98.8%

Vial size

10mg

DOCUMENTED RESEARCH AREAS

  • ▸Improved insulin sensitivity
  • ▸Enhanced cellular energy
  • ▸Balanced metabolic regulation
  • ▸Better fat burning
  • ▸Increased physical endurance
  • ▸Healthier blood sugar response

MECHANISM OF ACTION

MOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA. Research describes it translocating to the nucleus under metabolic stress and regulating the AMPK pathway and folate-methionine metabolism, positioning it as a signalling molecule that links mitochondrial status to whole-body metabolism in cell and animal studies.

  • ▸Activates the AMPK metabolic-sensing pathway in preclinical models
  • ▸Translocates to the nucleus to regulate stress-adaptive gene expression
  • ▸Exercise-responsive; studied as a marker of metabolic and muscle homeostasis

STUDY SUMMARIES

4 peer-reviewed references

Cell Metab · 2015

The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance

The discovery study reporting that MOTS-c activates AMPK and improved metabolic homeostasis and insulin sensitivity in mice.

View on PubMed (PMID 25738459)

Free Radic Biol Med · 2016

MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism

A review of MOTS-c as a regulator of muscle and fat metabolism and its proposed mitochondrial-to-nuclear signalling role.

View on PubMed (PMID 27216708)

Front Endocrinol (Lausanne) · 2023

MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation

A 2023 review summarising MOTS-c biology and its potential as a research target in metabolic and age-related conditions.

View on PubMed (PMID 36761202)

Biochim Biophys Acta Gen Subj · 2021

Mitochondrial-derived peptides and exercise

A review examining how exercise influences mitochondrial-derived peptides including MOTS-c.

View on PubMed (PMID 34520826)

CITATIONS

  1. 1.The mitochondrial-derived peptide MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metab. 2015. PMID 25738459. pubmed.ncbi.nlm.nih.gov/25738459
  2. 2.MOTS-c: A novel mitochondrial-derived peptide regulating muscle and fat metabolism. Free Radic Biol Med. 2016. PMID 27216708. pubmed.ncbi.nlm.nih.gov/27216708
  3. 3.MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation. Front Endocrinol (Lausanne). 2023. PMID 36761202. pubmed.ncbi.nlm.nih.gov/36761202
  4. 4.Mitochondrial-derived peptides and exercise. Biochim Biophys Acta Gen Subj. 2021. PMID 34520826. pubmed.ncbi.nlm.nih.gov/34520826

Citations describe findings reported in the referenced preclinical, in-vitro or clinical literature. They are provided for research and educational purposes only and are not a therapeutic claim.

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All information is provided for research and educational purposes only and describes findings in preclinical/in-vitro literature. Not medical advice. Products are supplied strictly for research purposes — not for human consumption.

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