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Semax navorsingspeptied

Navorsingsoorsig

Semax

ACTH(4–10)-analoog · neurotrofiese faktore

Janoshik HPLC-suiwerheidSertifikaat van AnaliseSlegs vir navorsingsdoeleindes

BESKIKBARE GROOTTES

IN SESTIG SEKONDES

  • • Die bes gedokumenteerde Russiese neuropeptied.
  • • Word byna altyd intranasaal in navorsing bestudeer.
  • • Susterpeptied van Selank (Cerebral Core-stapel).

MEGANISME

Semax (Met-Glu-His-Phe-Pro-Gly-Pro) is ’n fragment van die hormoon ACTH, verleng met Pro-Gly-Pro sodat dit nie binne minute afgebreek word nie. Dit is in die 1980’s by die Instituut vir Molekulêre Genetika in Moskou ontwikkel en is in Rusland geregistreer; elders bly dit ’n navorsingsverbinding.

Die kernbevinding in laboratoriummodelle is ’n vinnige toename in die uitdrukking van BDNF en NGF, twee neurotrofiese faktore wat neuronale oorlewing en sinaptiese plastisiteit onderhou. Dit word ook bestudeer vir die uitdrukking van VEGF en vir sy effek op die serotonien- en dopamienstelsels.

WAT DIE LITERATUUR DEK

  • BDNF- en NGF-uitdrukking in hippokampus-modelle
  • Geenuitdrukking-profiele ná isgemie in knaagdiere
  • Intranasale toediening in diere- en kliniese navorsing
  • Die Pro-Gly-Pro-fragment se eie literatuur

GEDOKUMENTEERDE NAVORSINGSAREAS

  • Sintetiese heptapeptied (Met-Glu-His-Phe-Pro-Gly-Pro)
  • Afgelei van die N-terminale fragment van ACTH(4–10)
  • Pro-Gly-Pro-verlenging vir metaboliese stabiliteit
  • Bestudeer in modelle van BDNF-, NGF- en VEGF-uitdrukking
  • 10 mg gevriesdroogde flessie, suiwerheid deur ’n derde party getoets
  • Verskaf slegs vir laboratoriumnavorsing

AANGEHAALDE STUDIES

Titels en bevindinge in Engels, soos gepubliseer.

  1. Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus

    Brain Res · 2006 · PMID 16996037

    In rats, Semax regulated expression of BDNF and its TrkB receptor in the hippocampus, supporting a neurotrophic mechanism.

  2. Semax binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain

    J Neurochem · 2006 · PMID 16635254

    Semax bound specifically in rat basal forebrain and increased BDNF protein levels.

  3. Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia

    Cell Mol Neurobiol · 2010 · PMID 19633950

    In a cerebral-ischemia model, Semax and its Pro-Gly-Pro metabolite activated transcription of neurotrophins and their receptors.

  4. The efficacy of semax in the treatment of patients at different stages of ischemic stroke

    Zh Nevrol Psikhiatr Im S S Korsakova · 2018 · PMID 29798983

    A clinical study evaluating Semax across different stages of ischemic stroke.

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