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Semax research peptide

Research Overview

Semax

Sharp, Clear Focus

HPLC-verified 98%Batch CoAResearch use only

OVERVIEW

Semax (Sharp, Clear Focus) is a research-grade peptide supplied by Living Water Labs for laboratory investigation. Sharper focus, faster recall and lasting mental clarity every day. Each batch is HPLC-verified to a minimum 98% purity with a batch-specific Certificate of Analysis. The summary below outlines documented mechanisms and study areas reported in the research literature.

Scientific name

ACTH(4-10) Pro-Gly-Pro Analog

Molecular weight

813.9 g/mol

Purity

99.1%

Vial size

10mg

DOCUMENTED RESEARCH AREAS

  • ▸Sharper focus and concentration
  • ▸Faster memory recall
  • ▸All-day mental clarity
  • ▸Protects brain health
  • ▸Lifts mood and motivation
  • ▸Reduces mental fatigue

MECHANISM OF ACTION

Semax is a synthetic heptapeptide based on a fragment of ACTH(4-10) with an added Pro-Gly-Pro tail for stability. Animal research reports that it raises brain BDNF and nerve-growth-factor signalling and modulates the dopaminergic and serotonergic systems, and it is studied as a neuroprotective and nootropic research peptide.

  • ▸Increases BDNF and TrkB expression in rodent hippocampus
  • ▸Activates neurotrophin gene transcription after experimental ischemia
  • ▸Modulates monoamine (dopamine/serotonin) systems in animal brain

STUDY SUMMARIES

4 peer-reviewed references

Brain Res · 2006

Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus

In rats, Semax regulated expression of BDNF and its TrkB receptor in the hippocampus, supporting a neurotrophic mechanism.

View on PubMed (PMID 16996037)

J Neurochem · 2006

Semax binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain

Semax bound specifically in rat basal forebrain and increased BDNF protein levels.

View on PubMed (PMID 16635254)

Cell Mol Neurobiol · 2010

Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia

In a cerebral-ischemia model, Semax and its Pro-Gly-Pro metabolite activated transcription of neurotrophins and their receptors.

View on PubMed (PMID 19633950)

Zh Nevrol Psikhiatr Im S S Korsakova · 2018

The efficacy of semax in the treatment of patients at different stages of ischemic stroke

A clinical study evaluating Semax across different stages of ischemic stroke.

View on PubMed (PMID 29798983)

CITATIONS

  1. 1.Semax, an analog of ACTH(4-10) with cognitive effects, regulates BDNF and trkB expression in the rat hippocampus. Brain Res. 2006. PMID 16996037. pubmed.ncbi.nlm.nih.gov/16996037
  2. 2.Semax binds specifically and increases levels of brain-derived neurotrophic factor protein in rat basal forebrain. J Neurochem. 2006. PMID 16635254. pubmed.ncbi.nlm.nih.gov/16635254
  3. 3.Semax and Pro-Gly-Pro activate the transcription of neurotrophins and their receptor genes after cerebral ischemia. Cell Mol Neurobiol. 2010. PMID 19633950. pubmed.ncbi.nlm.nih.gov/19633950
  4. 4.The efficacy of semax in the treatment of patients at different stages of ischemic stroke. Zh Nevrol Psikhiatr Im S S Korsakova. 2018. PMID 29798983. pubmed.ncbi.nlm.nih.gov/29798983

Citations describe findings reported in the referenced preclinical, in-vitro or clinical literature. They are provided for research and educational purposes only and are not a therapeutic claim.

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All information is provided for research and educational purposes only and describes findings in preclinical/in-vitro literature. Not medical advice. Products are supplied strictly for research purposes — not for human consumption.

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