Research compound encyclopedia
Melanocortin-system peptides
Peptides acting at melanocortin receptors (MC1R–MC5R): pigmentation, appetite and sexual-function research. Several are registered medicines elsewhere and named in SAHPRA warnings.
5 profiles · Melanocortin-agonist peptides such as melanotan are named in SAHPRA warnings; registered melanocortin medicines are prescription-only. Research use only.
In stock · research overviewMelanotan 2Melanotan II (MT-II) is a synthetic cyclic lactam heptapeptide analogue of alpha-melanocyte-stimulating hormone (alpha-MSH), designed at the University of Arizona as an enzymatically resistant, long-acting melanocortin.Melanotan I (Afamelanotide)A linear α-MSH analogue that selectively activates MC1R, approved (as an implant) to prevent phototoxicity in erythropoietic protoporphyria.In stock · research overviewPT-141 (Bremelanotide)A cyclic melanocortin-receptor agonist derived from melanotan II, approved in the US for hypoactive sexual desire disorder in premenopausal women.SetmelanotideA melanocortin-4 receptor agonist approved for rare genetic obesities caused by defects in the leptin–melanocortin pathway.α-MSH (Alpha-melanocyte-stimulating hormone)The natural 13-amino-acid melanocortin hormone cleaved from POMC — the template for every melanotan analogue.
Research reference only — not medical advice, no guidance on human use.