Research compound encyclopedia
Mitochondrial & longevity research compounds
Mitochondria-targeted peptides, mitochondrial-derived peptides and NAD+/mitophagy research compounds, studied for cellular energy metabolism and ageing biology.
16 profiles · Research compounds; not registered medicines for human use in South Africa unless stated otherwise.
ApelinAn endogenous peptide ligand of the APJ receptor, studied as an "exerkine" released by muscle during exercise.CarnosineA dipeptide (β-alanyl-L-histidine) abundant in muscle and brain, studied as a pH buffer, antioxidant and anti-glycation agent.FisetinA plant flavonoid (strawberries, apples) identified as one of the most potent natural senolytics in screening studies.FOXO4-DRIA D-retro-inverso peptide designed to disrupt the FOXO4–p53 interaction that keeps senescent cells alive — a senolytic research tool.In stock · research overviewGlutathioneGlutathione is the body’s principal endogenous antioxidant — a tripeptide (gamma-glutamyl-cysteinyl-glycine) that neutralises reactive oxygen species and supports phase-II detoxification and cellular redox balance.HumaninA 24-amino-acid peptide encoded in the mitochondrial genome — the first mitochondrial-derived peptide described — studied for cytoprotection.IrisinA myokine cleaved from the muscle membrane protein FNDC5 during exercise, studied for links between exercise, metabolism, bone and the brain.In stock · research overviewMOTS-cMOTS-c is a mitochondrial-derived peptide encoded within the 12S rRNA region of mitochondrial DNA.In stock · research overviewnadplusNAD+ (nicotinamide adenine dinucleotide) is the redox coenzyme at the centre of cellular energy metabolism and the substrate of sirtuins and PARPs; levels decline with age in many tissues.Nicotinamide Riboside (NR)A vitamin-B3-form NAD+ precursor that raises blood NAD+ in humans, tested in randomised trials in ageing and neurodegeneration.NMN (Nicotinamide Mononucleotide)A direct precursor of NAD+, studied in human trials as a way to raise NAD+ levels that decline with age.SHLP2 (Small Humanin-Like Peptide 2)A mitochondrial-derived peptide encoded in the 16S rRNA region, studied as an insulin sensitiser and cytoprotective signal.SpermidineA natural polyamine that induces autophagy, studied as a caloric-restriction mimetic and lifespan-extending compound in animals.SR9009 (Stenabolic)A synthetic ligand reported to activate REV-ERB circadian nuclear receptors — though later work showed REV-ERB-independent effects.In stock · research overviewSS-31 (Elamipretide)A mitochondria-targeted tetrapeptide that binds cardiolipin in the inner mitochondrial membrane — approved in the US in 2025 for Barth syndrome.Urolithin AA gut-microbiome metabolite of ellagitannins (pomegranate, berries, nuts) that stimulates mitophagy — the recycling of damaged mitochondria.
Research reference only — not medical advice, no guidance on human use.