Research compound encyclopedia
Growth-hormone secretagogues & GH-axis peptides
Compounds studied for how they act on the growth-hormone axis: GHRH analogues that act on the pituitary GHRH receptor, ghrelin-receptor (GHS-R1a) agonists, and the downstream IGF-1 system. Much of this literature comes from endocrine diagnostics and anti-doping work.
17 profiles · Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
ACE-031 (Ramatercept)A fusion protein of the activin type IIB receptor and an antibody Fc fragment that traps myostatin and related ligands.AnamorelinAn orally active, non-peptide ghrelin-receptor agonist approved in Japan for cancer cachexia — the best-trialled molecule in the secretagogue class.CJC-1295 (with DAC)A long-acting synthetic analogue of growth-hormone-releasing hormone (GHRH) carrying a Drug Affinity Complex that binds serum albumin.In stock · research overviewCJC-1295 without DAC (Mod GRF 1-29)A stabilised 29-amino-acid GHRH fragment with four amino-acid substitutions — the short-acting cousin of CJC-1295 with DAC.Follistatin (FS-344)A secreted glycoprotein that binds and neutralises myostatin and activin — studied as a route to muscle growth in muscle-disease research.GhrelinThe endogenous 28-amino-acid stomach hormone that activates the growth-hormone secretagogue receptor — the natural ligand every synthetic secretagogue imitates.GHRP-2 (Pralmorelin)A synthetic hexapeptide growth-hormone-releasing peptide that acts on the ghrelin receptor and is used in some countries as a diagnostic test of GH reserve.GHRP-6One of the first synthetic growth-hormone-releasing hexapeptides, a ghrelin-receptor agonist studied for GH release and as a diagnostic probe.HexarelinA potent synthetic growth-hormone-releasing hexapeptide with additional, receptor-mediated actions studied in cardiovascular models.Ibutamoren (MK-677)An orally active, non-peptide growth-hormone secretagogue that mimics ghrelin at the GHS-R1a receptor.IGF-1 LR3A recombinant analogue of insulin-like growth factor-1 with an Arg3 substitution and N-terminal extension that sharply reduces binding to IGF-binding proteins.In stock · research overviewIpamorelinIpamorelin is a synthetic pentapeptide that selectively binds the growth-hormone-secretagogue receptor (the ghrelin receptor).MacimorelinAn oral ghrelin-receptor agonist approved in the US and EU as a diagnostic test for adult growth-hormone deficiency.MGF (Mechano Growth Factor)A splice variant of the IGF-1 gene (IGF-IEc) produced in response to mechanical load, with a distinct E-domain peptide studied in tissue repair.OctreotideA long-acting synthetic analogue of somatostatin — the hormone that switches growth-hormone release off.SermorelinSynthetic GHRH(1-29) — the shortest fully active fragment of natural growth-hormone-releasing hormone, once a registered paediatric medicine.In stock · research overviewTesamorelinTesamorelin is a stabilised synthetic analogue of growth-hormone-releasing hormone (GHRH).
Research reference only — not medical advice, no guidance on human use.