Hormone, anabolic & androgen-receptor research compounds

Clomiphene Citrate

Also known as Clomid · clomifene

A selective oestrogen-receptor modulator that raises LH, FSH and testosterone by blocking oestrogen feedback — used off-label in male hypogonadism and infertility.

Research referenceNot stocked4 PubMed citations

In 60 seconds

Registered for female ovulation induction; used off-label in men, supported by systematic reviews. Meta-analyses summarise effects and adverse events; a 2025 study reported reduced IGF-1 after clomiphene in men.

  • A meta-analysis of clomiphene’s effects on testosterone in hypogonadal men.
  • A meta-analysis of clomiphene’s effects on semen quality and fertility.
  • Reported lower IGF-1 levels after clomiphene, proposed via oestrogen-SOCS-3 signalling.

Mechanism

Clomiphene is a mixture of zuclomiphene and enclomiphene isomers. Blocking oestrogen receptors at the hypothalamus increases gonadotropin release and therefore endogenous testosterone and spermatogenesis.

Research status

Registered for female ovulation induction; used off-label in men, supported by systematic reviews.

Key studies

  1. A meta-analysis of clomiphene’s effects on testosterone in hypogonadal men.

    Clomiphene citrate for men with hypogonadism: a systematic review and meta-analysis — Andrology, 2022 · PMID 34933414

  2. A meta-analysis of clomiphene’s effects on semen quality and fertility.

    Clomiphene citrate for male infertility: A systematic review and meta-analysis — Andrology, 2023 · PMID 36680549

  3. Reported lower IGF-1 levels after clomiphene, proposed via oestrogen-SOCS-3 signalling.

    Reduced IGF-1 Levels Following Clomiphene Treatment for Male Hypogonadism — J Endocr Soc, 2025 · PMID 40421427

  4. Reviews mechanisms and clinical implications of clomiphene for male hypogonadism.

    Clomiphene Citrate Treatment as an Alternative Therapeutic Approach for Male Hypogonadism: Mechanisms and Clinical Implications — Pharmaceuticals (Basel), 2024 · PMID 39338395

Safety signals in the literature

Meta-analyses summarise effects and adverse events; a 2025 study reported reduced IGF-1 after clomiphene in men.

Androgens and anabolic steroids are scheduled substances in South Africa (prescription-only under the Medicines and Related Substances Act) and are prohibited in sport. SARM-class compounds are unapproved for human use anywhere. Educational content only — no use guidance.

Questions

What is Clomiphene Citrate?

A selective oestrogen-receptor modulator that raises LH, FSH and testosterone by blocking oestrogen feedback — used off-label in male hypogonadism and infertility. Clomiphene is a mixture of zuclomiphene and enclomiphene isomers. Blocking oestrogen receptors at the hypothalamus increases gonadotropin release and therefore endogenous testosterone and spermatogenesis.

What is the research status of Clomiphene Citrate?

Registered for female ovulation induction; used off-label in men, supported by systematic reviews.

What safety signals are reported for Clomiphene Citrate?

Meta-analyses summarise effects and adverse events; a 2025 study reported reduced IGF-1 after clomiphene in men.

Does Living Water Labs stock Clomiphene Citrate?

Not at present. Clomiphene Citrate is profiled here for reference, with citations to the published literature. Androgens and anabolic steroids are scheduled substances in South Africa (prescription-only under the Medicines and Related Substances Act) and are prohibited in sport. SARM-class compounds are unapproved for human use anywhere. Educational content only — no use guidance.

More in Hormone & anabolic

Testosterone CypionateA long-chain ester of testosterone given by intramuscular or subcutaneous injection, used clinically in testosterone deficiency and gender-affirming care.Testosterone EnanthateA testosterone ester with a heptanoate chain, one of the oldest injectable androgen preparations.Nandrolone DecanoateA 19-nortestosterone anabolic steroid with a high anabolic-to-androgenic ratio, used clinically in some anaemia, osteoporosis and wasting settings.TrenboloneA potent 19-nor anabolic steroid approved only as a veterinary growth promoter for cattle — never as a human medicine.OxandroloneAn oral anabolic steroid studied clinically for severe burns, muscle wasting and Duchenne dystrophy.Enclomiphene CitrateThe trans-isomer of clomiphene — an oral oestrogen-receptor antagonist that raises LH, FSH and testosterone while preserving sperm production.

Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.

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