Hormone, anabolic & androgen-receptor research compounds

Enclomiphene Citrate

Also known as Androxal · trans-clomiphene

The trans-isomer of clomiphene — an oral oestrogen-receptor antagonist that raises LH, FSH and testosterone while preserving sperm production.

Research referenceNot stocked4 PubMed citations

In 60 seconds

Phase 2/3 trials in secondary hypogonadism (2013–2016); not approved by major regulators. Trials report it as generally tolerated; reviews compare its profile with clomiphene, whose cis-isomer has longer persistence.

  • A phase 3 randomised trial compared enclomiphene with topical testosterone on testosterone, LH, FSH and sperm counts.
  • A phase 2 trial found enclomiphene raised testosterone while avoiding the oligospermia seen with topical testosterone.
  • A meta-analysis of randomised trials of clomiphene and enclomiphene in male hypogonadism.

Mechanism

By blocking oestrogen feedback at the hypothalamus and pituitary, enclomiphene increases gonadotropin release, so the testes make more of their own testosterone. Unlike exogenous testosterone, it does not suppress spermatogenesis.

Research status

Phase 2/3 trials in secondary hypogonadism (2013–2016); not approved by major regulators. Clomiphene itself is used off-label.

Key studies

  1. A phase 3 randomised trial compared enclomiphene with topical testosterone on testosterone, LH, FSH and sperm counts.

    Oral enclomiphene citrate raises testosterone and preserves sperm counts in obese hypogonadal men, unlike topical testosterone: restoration instead of replacement — BJU Int, 2016 · PMID 26496621

  2. A phase 2 trial found enclomiphene raised testosterone while avoiding the oligospermia seen with topical testosterone.

    Enclomiphene citrate stimulates testosterone production while preventing oligospermia: a randomized phase II clinical trial comparing topical testosterone — Fertil Steril, 2014 · PMID 25044085

  3. A meta-analysis of randomised trials of clomiphene and enclomiphene in male hypogonadism.

    Clomiphene or enclomiphene citrate for the treatment of male hypogonadism: a systematic review and meta-analysis of randomized controlled trials — Arch Endocrinol Metab, 2025 · PMID 41066380

  4. Compared the benefits and risks of enclomiphene and clomiphene.

    Safety and efficacy of enclomiphene and clomiphene for hypogonadal men — Transl Androl Urol, 2024 · PMID 39434750

Safety signals in the literature

Trials report it as generally tolerated; reviews compare its profile with clomiphene, whose cis-isomer has longer persistence.

Androgens and anabolic steroids are scheduled substances in South Africa (prescription-only under the Medicines and Related Substances Act) and are prohibited in sport. SARM-class compounds are unapproved for human use anywhere. Educational content only — no use guidance.

Questions

What is Enclomiphene Citrate?

The trans-isomer of clomiphene — an oral oestrogen-receptor antagonist that raises LH, FSH and testosterone while preserving sperm production. By blocking oestrogen feedback at the hypothalamus and pituitary, enclomiphene increases gonadotropin release, so the testes make more of their own testosterone. Unlike exogenous testosterone, it does not suppress spermatogenesis.

What is the research status of Enclomiphene Citrate?

Phase 2/3 trials in secondary hypogonadism (2013–2016); not approved by major regulators. Clomiphene itself is used off-label.

What safety signals are reported for Enclomiphene Citrate?

Trials report it as generally tolerated; reviews compare its profile with clomiphene, whose cis-isomer has longer persistence.

Does Living Water Labs stock Enclomiphene Citrate?

Not at present. Enclomiphene Citrate is profiled here for reference, with citations to the published literature. Androgens and anabolic steroids are scheduled substances in South Africa (prescription-only under the Medicines and Related Substances Act) and are prohibited in sport. SARM-class compounds are unapproved for human use anywhere. Educational content only — no use guidance.

More in Hormone & anabolic

Testosterone CypionateA long-chain ester of testosterone given by intramuscular or subcutaneous injection, used clinically in testosterone deficiency and gender-affirming care.Testosterone EnanthateA testosterone ester with a heptanoate chain, one of the oldest injectable androgen preparations.Nandrolone DecanoateA 19-nortestosterone anabolic steroid with a high anabolic-to-androgenic ratio, used clinically in some anaemia, osteoporosis and wasting settings.TrenboloneA potent 19-nor anabolic steroid approved only as a veterinary growth promoter for cattle — never as a human medicine.OxandroloneAn oral anabolic steroid studied clinically for severe burns, muscle wasting and Duchenne dystrophy.Enobosarm (Ostarine)A non-steroidal selective androgen receptor modulator (SARM) taken orally, studied for cancer cachexia and AR-positive breast cancer.

Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.

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