Hormone, anabolic & androgen-receptor research compounds
Enobosarm (Ostarine)
Also known as ostarine · MK-2866 · GTx-024 · S-22
A non-steroidal selective androgen receptor modulator (SARM) taken orally, studied for cancer cachexia and AR-positive breast cancer.
In 60 seconds
Phase 2/3 trials (cachexia, breast cancer); never approved. Pharmacovigilance reviews link SARM use to drug-induced liver injury; preclinical work reports cardiomyocyte toxicity at high exposure.
- Reviews enobosarm’s development for muscle wasting and cachexia.
- A phase 2 trial evaluated enobosarm’s activity and safety in AR+/ER+ advanced breast cancer.
- Analysed suspected SARM adverse-event reports, including drug-induced liver injury.
Mechanism
SARMs bind the androgen receptor with tissue-selective effects, aiming for anabolic action in muscle and bone with less effect on prostate and skin. Enobosarm is the most clinically studied SARM.
Research status
Phase 2/3 trials (cachexia, breast cancer); never approved. Banned in sport and sold illicitly as a "research chemical".
Key studies
Reviews enobosarm’s development for muscle wasting and cachexia.
Enobosarm (GTx-024, S-22): a potential treatment for cachexia — Future Oncol, 2014 · PMID 24490605
A phase 2 trial evaluated enobosarm’s activity and safety in AR+/ER+ advanced breast cancer.
Activity and safety of enobosarm, a novel, oral, selective androgen receptor modulator, in androgen receptor-positive, oestrogen receptor-positive, and HER2-negative advanced breast cancer (Study G200802): a randomised, open-label, multicentre, multinational, parallel design, phase 2 trial — Lancet Oncol, 2024 · PMID 38342115
Analysed suspected SARM adverse-event reports, including drug-induced liver injury.
Selective androgen receptor modulator use and related adverse events including drug-induced liver injury: Analysis of suspected cases — Eur J Clin Pharmacol, 2024 · PMID 38059982
Reported sex-specific cytotoxic effects of ostarine in cardiomyocytes in vitro.
Sex-specific cytotoxicity of ostarine in cardiomyocytes — Mol Cell Endocrinol, 2023 · PMID 37543162
Safety signals in the literature
Pharmacovigilance reviews link SARM use to drug-induced liver injury; preclinical work reports cardiomyocyte toxicity at high exposure.
Legal status (South Africa)
Androgens and anabolic steroids are scheduled substances in South Africa (prescription-only under the Medicines and Related Substances Act) and are prohibited in sport. SARM-class compounds are unapproved for human use anywhere. Educational content only — no use guidance.
Questions
What is Enobosarm (Ostarine)?
A non-steroidal selective androgen receptor modulator (SARM) taken orally, studied for cancer cachexia and AR-positive breast cancer. SARMs bind the androgen receptor with tissue-selective effects, aiming for anabolic action in muscle and bone with less effect on prostate and skin. Enobosarm is the most clinically studied SARM.
What is the research status of Enobosarm (Ostarine)?
Phase 2/3 trials (cachexia, breast cancer); never approved. Banned in sport and sold illicitly as a "research chemical".
What safety signals are reported for Enobosarm (Ostarine)?
Pharmacovigilance reviews link SARM use to drug-induced liver injury; preclinical work reports cardiomyocyte toxicity at high exposure.
Does Living Water Labs stock Enobosarm (Ostarine)?
Not at present. Enobosarm (Ostarine) is profiled here for reference, with citations to the published literature. Androgens and anabolic steroids are scheduled substances in South Africa (prescription-only under the Medicines and Related Substances Act) and are prohibited in sport. SARM-class compounds are unapproved for human use anywhere. Educational content only — no use guidance.
More in Hormone & anabolic
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.