Hormone, anabolic & androgen-receptor research compounds
RAD-140 (Testolone)
Also known as RAD140 · testolone · vosilasarm
A non-steroidal SARM studied in breast-cancer models and neuroprotection, found in illicit "bodybuilding" supplements.
In 60 seconds
Early clinical development in breast cancer (vosilasarm); not approved. Several case reports describe drug-induced liver injury from RAD-140-containing supplements; a 2024 case linked such a supplement to gynaecomastia and hypogonadism.
- In AR/ER-positive breast-cancer models, RAD140 inhibited tumour growth.
- RAD140 was neuroprotective in cultured neurons and in a rat kainate-lesion model.
- Case report of idiosyncratic liver injury associated with RAD140.
Mechanism
RAD-140 is an androgen-receptor agonist in muscle and bone with antagonist-like effects in some breast-cancer models; preclinically it has neuroprotective actions in cultured neurons.
Research status
Early clinical development in breast cancer (vosilasarm); not approved.
Key studies
In AR/ER-positive breast-cancer models, RAD140 inhibited tumour growth.
Selective Androgen Receptor Modulator RAD140 Inhibits the Growth of Androgen/Estrogen Receptor-Positive Breast Cancer Models with a Distinct Mechanism of Action — Clin Cancer Res, 2017 · PMID 28974548
RAD140 was neuroprotective in cultured neurons and in a rat kainate-lesion model.
Selective androgen receptor modulator RAD140 is neuroprotective in cultured neurons and kainate-lesioned male rats — Endocrinology, 2014 · PMID 24428527
Case report of idiosyncratic liver injury associated with RAD140.
Idiosyncratic drug-induced liver injury related to use of novel selective androgen receptor modulator RAD140 (Testalone): a case report — J Med Case Rep, 2023 · PMID 36978171
Liver injury in a 52-year-old man after supplements containing RAD-140 and LGD-4033.
Drug-Induced Liver Injury Associated With Alpha Bolic (RAD-140) and Alpha Elite (RAD-140 and LGD-4033) — ACG Case Rep J, 2020 · PMID 33062783
Safety signals in the literature
Several case reports describe drug-induced liver injury from RAD-140-containing supplements; a 2024 case linked such a supplement to gynaecomastia and hypogonadism.
Legal status (South Africa)
Androgens and anabolic steroids are scheduled substances in South Africa (prescription-only under the Medicines and Related Substances Act) and are prohibited in sport. SARM-class compounds are unapproved for human use anywhere. Educational content only — no use guidance.
Questions
What is RAD-140 (Testolone)?
A non-steroidal SARM studied in breast-cancer models and neuroprotection, found in illicit "bodybuilding" supplements. RAD-140 is an androgen-receptor agonist in muscle and bone with antagonist-like effects in some breast-cancer models; preclinically it has neuroprotective actions in cultured neurons.
What is the research status of RAD-140 (Testolone)?
Early clinical development in breast cancer (vosilasarm); not approved.
What safety signals are reported for RAD-140 (Testolone)?
Several case reports describe drug-induced liver injury from RAD-140-containing supplements; a 2024 case linked such a supplement to gynaecomastia and hypogonadism.
Does Living Water Labs stock RAD-140 (Testolone)?
Not at present. RAD-140 (Testolone) is profiled here for reference, with citations to the published literature. Androgens and anabolic steroids are scheduled substances in South Africa (prescription-only under the Medicines and Related Substances Act) and are prohibited in sport. SARM-class compounds are unapproved for human use anywhere. Educational content only — no use guidance.
More in Hormone & anabolic
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.