Incretin & metabolic research compounds
Exenatide
Also known as exendin-4 · Byetta · Bydureon
A synthetic version of exendin-4, a 39-amino-acid peptide from Gila monster venom and the first GLP-1 receptor agonist approved as a medicine.
In 60 seconds
Approved for type 2 diabetes (twice-daily and weekly forms); extensively used in preclinical research including neuro and β-cell studies. Nausea is the characteristic early effect; reviews cover pharmacokinetics, adverse effects and interactions.
- Reviews exenatide’s pharmacology, pharmacokinetics, efficacy and adverse effects; derived from Gila monster saliva.
- A development review of exenatide (synthetic exendin-4), a 39-amino-acid GLP-1 agonist.
- In a mouse xenograft system, exendin-4 combined with harmine expanded human β-cell mass.
Mechanism
Exendin-4 shares about 53% homology with GLP-1 but resists DPP-4 degradation. It is a full GLP-1 receptor agonist, enhancing glucose-dependent insulin release, suppressing glucagon and slowing gastric emptying. It remains a standard research tool for GLP-1 receptor biology.
Research status
Approved for type 2 diabetes (twice-daily and weekly forms); extensively used in preclinical research including neuro and β-cell studies.
Key studies
Reviews exenatide’s pharmacology, pharmacokinetics, efficacy and adverse effects; derived from Gila monster saliva.
Exenatide — Am J Health Syst Pharm, 2006 · PMID 16484515
A development review of exenatide (synthetic exendin-4), a 39-amino-acid GLP-1 agonist.
Exenatide. Amylin/Eli Lilly — Curr Opin Investig Drugs, 2003 · PMID 12808888
In a mouse xenograft system, exendin-4 combined with harmine expanded human β-cell mass.
Harmine and exendin-4 combination therapy safely expands human β cell mass in vivo in a mouse xenograft system — Sci Transl Med, 2024 · PMID 38985854
In a diabetic model, exendin-4 reduced tau hyperphosphorylation via the Wnt/β-catenin pathway.
Exendin-4 ameliorates tau hyperphosphorylation and cognitive impairment in type 2 diabetes through acting on Wnt/β-catenin/NeuroD1 pathway — Mol Med, 2023 · PMID 37667187
Safety signals in the literature
Nausea is the characteristic early effect; reviews cover pharmacokinetics, adverse effects and interactions.
Legal status (South Africa)
Approved incretin medicines are prescription-only (scheduled) in South Africa and available only through a prescriber; research-grade material is not a medicine and is not for human use.
Related compounds we stock
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Comparisons
Questions
What is Exenatide?
A synthetic version of exendin-4, a 39-amino-acid peptide from Gila monster venom and the first GLP-1 receptor agonist approved as a medicine. Exendin-4 shares about 53% homology with GLP-1 but resists DPP-4 degradation. It is a full GLP-1 receptor agonist, enhancing glucose-dependent insulin release, suppressing glucagon and slowing gastric emptying. It remains a standard research tool for GLP-1 receptor biology.
What is the research status of Exenatide?
Approved for type 2 diabetes (twice-daily and weekly forms); extensively used in preclinical research including neuro and β-cell studies.
What safety signals are reported for Exenatide?
Nausea is the characteristic early effect; reviews cover pharmacokinetics, adverse effects and interactions.
Does Living Water Labs stock Exenatide?
Not at present. Exenatide is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Approved incretin medicines are prescription-only (scheduled) in South Africa and available only through a prescriber; research-grade material is not a medicine and is not for human use.
More in Incretin & metabolic
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
