Incretin & metabolic research compounds
AOD-9604
Also known as AOD9604 · hGH fragment 176-191 · Tyr-hGH 177-191
A modified C-terminal fragment of human growth hormone (residues 177–191 plus an N-terminal tyrosine) studied for fat metabolism without GH’s growth or glucose effects.
In 60 seconds
Reached phase 2 obesity trials in the early 2000s; not approved as a medicine. Development-era trials reported it as tolerated; it is detected in anti-doping testing.
- In obese mice, chronic AOD9604 increased fat oxidation and reduced body weight, and the effect was not mediated by the GH receptor.
- Long-term hGH 177-191 treatment reduced body-weight gain and adipose mass in ob/ob mice.
- Studied intra-articular AOD9604 with or without hyaluronic acid in a rabbit collagenase osteoarthritis model.
Mechanism
The 177–191 region of GH is associated with lipolytic activity. AOD-9604 was designed to mimic that fat-metabolism effect without activating the full GH receptor programme, so it does not raise IGF-1.
Research status
Reached phase 2 obesity trials in the early 2000s; not approved as a medicine. Also studied in an animal osteoarthritis model.
Key studies
In obese mice, chronic AOD9604 increased fat oxidation and reduced body weight, and the effect was not mediated by the GH receptor.
Increase of fat oxidation and weight loss in obese mice caused by chronic treatment with human growth hormone or a modified C-terminal fragment — Int J Obes Relat Metab Disord, 2001 · PMID 11673763
Long-term hGH 177-191 treatment reduced body-weight gain and adipose mass in ob/ob mice.
Reduction of cumulative body weight gain and adipose tissue mass in obese mice: response to chronic treatment with synthetic hGH 177-191 peptide — Biochem Mol Biol Int, 1994 · PMID 7987248
Studied intra-articular AOD9604 with or without hyaluronic acid in a rabbit collagenase osteoarthritis model.
Effect of Intra-articular Injection of AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model — Ann Clin Lab Sci, 2015 · PMID 26275694
Characterised AOD9604 metabolism and detection for anti-doping testing.
Detection and in vitro metabolism of AOD9604 — Drug Test Anal, 2015 · PMID 25208511
Safety signals in the literature
Development-era trials reported it as tolerated; it is detected in anti-doping testing. Human efficacy for weight was not established.
Legal status (South Africa)
Approved incretin medicines are prescription-only (scheduled) in South Africa and available only through a prescriber; research-grade material is not a medicine and is not for human use.
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Comparisons
Questions
What is AOD-9604?
A modified C-terminal fragment of human growth hormone (residues 177–191 plus an N-terminal tyrosine) studied for fat metabolism without GH’s growth or glucose effects. The 177–191 region of GH is associated with lipolytic activity. AOD-9604 was designed to mimic that fat-metabolism effect without activating the full GH receptor programme, so it does not raise IGF-1.
What is the research status of AOD-9604?
Reached phase 2 obesity trials in the early 2000s; not approved as a medicine. Also studied in an animal osteoarthritis model.
What safety signals are reported for AOD-9604?
Development-era trials reported it as tolerated; it is detected in anti-doping testing. Human efficacy for weight was not established.
Does Living Water Labs stock AOD-9604?
Not at present. AOD-9604 is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Approved incretin medicines are prescription-only (scheduled) in South Africa and available only through a prescriber; research-grade material is not a medicine and is not for human use.
More in Incretin & metabolic
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
