Reproductive-axis (HPG) peptides
hMG (Human Menopausal Gonadotropin)
Also known as human menopausal gonadotropin · menotropin · menotrophin
A gonadotropin preparation purified from urine that carries both FSH and LH activity, used in assisted reproduction.
In 60 seconds
Registered prescription fertility medicine, used under specialist supervision in IVF/ICSI cycles and in some male hypogonadotropic hypogonadism protocols. In IVF meta-analyses, ovarian hyperstimulation syndrome rates were not significantly different from recombinant FSH.
- A meta-analysis of IVF/ICSI cycles reported a higher live-birth rate with hMG than recombinant FSH (OR 1.20), with no significant difference in OHSS rates.
- Across five randomised trials, ongoing pregnancy and live-birth rates were similar between highly purified hMG and recombinant FSH.
- In 29 gonadotrophin-deficient men on gonadotrophin therapy, median time to any sperm in the ejaculate was about 5.5 months and conception occurred in 22 of 43 treatment courses.
Mechanism
hMG supplies follicle-stimulating hormone (FSH), which drives follicle growth in the ovary and supports spermatogenesis in the testis, together with luteinising-hormone (LH) activity, which acts on theca and Leydig cells. That LH component is what separates it from FSH-only preparations.
Research status
Registered prescription fertility medicine, used under specialist supervision in IVF/ICSI cycles and in some male hypogonadotropic hypogonadism protocols.
Key studies
A meta-analysis of IVF/ICSI cycles reported a higher live-birth rate with hMG than recombinant FSH (OR 1.20), with no significant difference in OHSS rates.
Efficacy and safety of human menopausal gonadotrophins versus recombinant FSH: a meta-analysis — Reprod Biomed Online, 2008 · PMID 18252052
Across five randomised trials, ongoing pregnancy and live-birth rates were similar between highly purified hMG and recombinant FSH.
Clinical efficacy of highly purified hMG versus recombinant FSH in IVF/ICSI cycles: a meta-analysis — Gynecol Obstet Invest, 2010 · PMID 20389096
In 29 gonadotrophin-deficient men on gonadotrophin therapy, median time to any sperm in the ejaculate was about 5.5 months and conception occurred in 22 of 43 treatment courses.
Predicting pregnancy and spermatogenesis by survival analysis during gonadotrophin treatment of gonadotrophin-deficient infertile men — Hum Reprod, 2002 · PMID 11870114
Safety signals in the literature
In IVF meta-analyses, ovarian hyperstimulation syndrome rates were not significantly different from recombinant FSH. It is a clinical medicine with specialist monitoring.
Legal status (South Africa)
Gonadotropins and GnRH analogues are scheduled prescription medicines in South Africa; research use only.
Now in the catalogue
hMG (Human Menopausal Gonadotropin) is now in our catalogue as a research vial. Pre-orders are 10% off until the 15 October delivery lands.
Comparisons
Questions
What is hMG (Human Menopausal Gonadotropin)?
A gonadotropin preparation purified from urine that carries both FSH and LH activity, used in assisted reproduction. hMG supplies follicle-stimulating hormone (FSH), which drives follicle growth in the ovary and supports spermatogenesis in the testis, together with luteinising-hormone (LH) activity, which acts on theca and Leydig cells. That LH component is what separates it from FSH-only preparations.
What is the research status of hMG (Human Menopausal Gonadotropin)?
Registered prescription fertility medicine, used under specialist supervision in IVF/ICSI cycles and in some male hypogonadotropic hypogonadism protocols.
What safety signals are reported for hMG (Human Menopausal Gonadotropin)?
In IVF meta-analyses, ovarian hyperstimulation syndrome rates were not significantly different from recombinant FSH. It is a clinical medicine with specialist monitoring.
Does Living Water Labs stock hMG (Human Menopausal Gonadotropin)?
Not at present. hMG (Human Menopausal Gonadotropin) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Gonadotropins and GnRH analogues are scheduled prescription medicines in South Africa; research use only.
Deep dives
More in Reproductive axis
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
