Reproductive-axis (HPG) peptides
Triptorelin
Also known as Decapeptyl · Trelstar · triptorelin pamoate
A GnRH-agonist decapeptide with a D-tryptophan at position 6, used to suppress sex hormones and in assisted reproduction.
In 60 seconds
Registered medicine (prostate cancer, endometriosis, adjuvant breast cancer, central precocious puberty, fertility). As with other GnRH agonists, effects follow from sex-steroid suppression after an initial flare.
- Explains how a D-amino acid at position 6 increases enzymatic resistance and receptor affinity.
- Reviews a 6-month triptorelin formulation for advanced prostate cancer.
- Reviews triptorelin with tamoxifen or an aromatase inhibitor as adjuvant breast-cancer therapy.
Mechanism
The D-amino-acid substitution at position 6 resists breakdown and raises receptor affinity. Continuous dosing suppresses gonadal steroids; single doses are used to trigger ovulation in IVF protocols.
Research status
Registered medicine (prostate cancer, endometriosis, adjuvant breast cancer, central precocious puberty, fertility).
Key studies
Explains how a D-amino acid at position 6 increases enzymatic resistance and receptor affinity.
[Pharmacokinetics and pharmacodynamics of triptorelin] — Ann Urol (Paris), 2005 · PMID 16302716
Reviews a 6-month triptorelin formulation for advanced prostate cancer.
Triptorelin embonate (6-month formulation) — Drugs, 2010 · PMID 20166771
Reviews triptorelin with tamoxifen or an aromatase inhibitor as adjuvant breast-cancer therapy.
Triptorelin: A Review of its Use as an Adjuvant Anticancer Therapy in Early Breast Cancer — Drugs, 2017 · PMID 29177573
Reviews GnRH-agonist (triptorelin) use to induce a hypo-oestrogenic state in endometriosis.
Triptorelin for the treatment of endometriosis — Expert Opin Pharmacother, 2014 · PMID 24832495
Safety signals in the literature
As with other GnRH agonists, effects follow from sex-steroid suppression after an initial flare.
Legal status (South Africa)
Gonadotropins and GnRH analogues are scheduled prescription medicines in South Africa; research use only.
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Tell us you want Triptorelin and we’ll email you if we add it. Requests decide what we source next.
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Comparisons
Questions
What is Triptorelin?
A GnRH-agonist decapeptide with a D-tryptophan at position 6, used to suppress sex hormones and in assisted reproduction. The D-amino-acid substitution at position 6 resists breakdown and raises receptor affinity. Continuous dosing suppresses gonadal steroids; single doses are used to trigger ovulation in IVF protocols.
What is the research status of Triptorelin?
Registered medicine (prostate cancer, endometriosis, adjuvant breast cancer, central precocious puberty, fertility).
What safety signals are reported for Triptorelin?
As with other GnRH agonists, effects follow from sex-steroid suppression after an initial flare.
Does Living Water Labs stock Triptorelin?
Not at present. Triptorelin is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Gonadotropins and GnRH analogues are scheduled prescription medicines in South Africa; research use only.
More in Reproductive axis
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
