Reproductive-axis (HPG) peptides
Kisspeptin-10
Also known as kisspeptin · metastin 45-54 · KP-10
The shortest active fragment of kisspeptin, the hypothalamic peptide that triggers GnRH release and sits at the top of the reproductive axis.
In 60 seconds
Human research tool in reproductive endocrinology (fertility, hypothalamic amenorrhoea); not an approved medicine. Short-term human studies are physiological; repeated exposure can desensitise the axis in some protocols.
- Reviews kisspeptin as the critical central regulator of GnRH release.
- Reviews how metabolic signals act on kisspeptin neurons to link energy balance and fertility.
- Reviews kisspeptin and neurokinin B in puberty, the menstrual cycle and menopause.
Mechanism
Kisspeptin binds its receptor (KISS1R/GPR54) on GnRH neurons, driving GnRH pulses and therefore LH, FSH and testosterone/oestrogen. Kisspeptin neurons integrate metabolic and stress signals, linking energy balance to fertility.
Research status
Human research tool in reproductive endocrinology (fertility, hypothalamic amenorrhoea); not an approved medicine.
Key studies
Reviews kisspeptin as the critical central regulator of GnRH release.
The Role of Kisspeptin in the Control of the Hypothalamic-Pituitary-Gonadal Axis and Reproduction — Front Endocrinol (Lausanne), 2022 · PMID 35837314
Reviews how metabolic signals act on kisspeptin neurons to link energy balance and fertility.
Metabolic regulation of kisspeptin - the link between energy balance and reproduction — Nat Rev Endocrinol, 2020 · PMID 32427949
Reviews kisspeptin and neurokinin B in puberty, the menstrual cycle and menopause.
Kisspeptin and neurokinin B: roles in reproductive health — Physiol Rev, 2025 · PMID 39813600
In mice, kisspeptin-10 acting on osteoclast GPR54 prevented age-related bone loss.
Kisspeptin-10 binding to Gpr54 in osteoclasts prevents bone loss by activating Dusp18-mediated dephosphorylation of Src — Nat Commun, 2024 · PMID 38346942
Safety signals in the literature
Short-term human studies are physiological; repeated exposure can desensitise the axis in some protocols. A 2024 study also found KISS1R signalling in osteoclasts.
Legal status (South Africa)
Gonadotropins and GnRH analogues are scheduled prescription medicines in South Africa; research use only.
Now in the catalogue
Kisspeptin-10 is now in our catalogue as a research vial. Pre-orders are 10% off until the 15 October delivery lands.
Comparisons
Questions
What is Kisspeptin-10?
The shortest active fragment of kisspeptin, the hypothalamic peptide that triggers GnRH release and sits at the top of the reproductive axis. Kisspeptin binds its receptor (KISS1R/GPR54) on GnRH neurons, driving GnRH pulses and therefore LH, FSH and testosterone/oestrogen. Kisspeptin neurons integrate metabolic and stress signals, linking energy balance to fertility.
What is the research status of Kisspeptin-10?
Human research tool in reproductive endocrinology (fertility, hypothalamic amenorrhoea); not an approved medicine.
What safety signals are reported for Kisspeptin-10?
Short-term human studies are physiological; repeated exposure can desensitise the axis in some protocols. A 2024 study also found KISS1R signalling in osteoclasts.
Does Living Water Labs stock Kisspeptin-10?
Not at present. Kisspeptin-10 is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Gonadotropins and GnRH analogues are scheduled prescription medicines in South Africa; research use only.
Deep dives
More in Reproductive axis
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
