Cosmetic & skin-signalling peptides
Matrixyl (Palmitoyl Pentapeptide-4)
Also known as pal-KTTKS · palmitoyl pentapeptide-3 · palmitoyl pentapeptide-4
A lipidated fragment of type I pro-collagen (Lys-Thr-Thr-Lys-Ser) used as a topical "signal peptide" to stimulate matrix production.
In 60 seconds
Cosmetic ingredient with small clinical studies and in-vitro work; delivery systems remain an active topic. Topical studies report good tolerability.
- A clinical study measured changes in photoaged facial skin with topical pal-KTTKS.
- Compared the stability and skin permeation of KTTKS and its palmitoylated form.
- Studied pal-KTTKS effects on fibroblast contractility and pro-fibrotic mediators.
Mechanism
KTTKS is a pro-collagen subfragment reported to feed back on fibroblasts to increase collagen and other matrix components; the palmitoyl chain improves skin penetration and stability.
Research status
Cosmetic ingredient with small clinical studies and in-vitro work; delivery systems remain an active topic.
Key studies
A clinical study measured changes in photoaged facial skin with topical pal-KTTKS.
Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin — Int J Cosmet Sci, 2005 · PMID 18492182
Compared the stability and skin permeation of KTTKS and its palmitoylated form.
Dermal Stability and In Vitro Skin Permeation of Collagen Pentapeptides (KTTKS and palmitoyl-KTTKS) — Biomol Ther (Seoul), 2014 · PMID 25143811
Studied pal-KTTKS effects on fibroblast contractility and pro-fibrotic mediators.
Effect of Palmitoyl-Pentapeptide (Pal-KTTKS) on Wound Contractile Process in Relation with Connective Tissue Growth Factor and α-Smooth Muscle Actin Expression — Tissue Eng Regen Med, 2017 · PMID 30603464
Characterised liposomal encapsulation of pal-KTTKS for delivery.
Liposome Encapsulation of the Palmitoyl-KTTKS Peptide: Structural and Functional Characterization — Pharmaceutics, 2024 · PMID 38399273
Safety signals in the literature
Topical studies report good tolerability.
Legal status (South Africa)
Cosmetic-ingredient peptides; research use only in the form we would supply.
Related compounds we stock
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Comparisons
Questions
What is Matrixyl (Palmitoyl Pentapeptide-4)?
A lipidated fragment of type I pro-collagen (Lys-Thr-Thr-Lys-Ser) used as a topical "signal peptide" to stimulate matrix production. KTTKS is a pro-collagen subfragment reported to feed back on fibroblasts to increase collagen and other matrix components; the palmitoyl chain improves skin penetration and stability.
What is the research status of Matrixyl (Palmitoyl Pentapeptide-4)?
Cosmetic ingredient with small clinical studies and in-vitro work; delivery systems remain an active topic.
What safety signals are reported for Matrixyl (Palmitoyl Pentapeptide-4)?
Topical studies report good tolerability.
Does Living Water Labs stock Matrixyl (Palmitoyl Pentapeptide-4)?
Not at present. Matrixyl (Palmitoyl Pentapeptide-4) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Cosmetic-ingredient peptides; research use only in the form we would supply.
More in Skin peptides
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
