Cosmetic & skin-signalling peptides
SNAP-8 (Acetyl Octapeptide-3)
Also known as acetyl octapeptide-3 · acetyl glutamyl heptapeptide-3 · snap 8 · snap8
An eight-amino-acid extension of Argireline, designed as a topical expression-line peptide that targets the same SNARE complex.
In 60 seconds
A cosmetic ingredient. Patch studies that included it reported good dermal tolerability; systemic data do not exist because it is a topical cosmetic ingredient.
- The parent peptide: Argireline was designed to interfere with SNARE-complex formation and showed anti-wrinkle activity in an emulsion study.
- A 12-week clinical study of a hyaluronic-acid microneedle patch whose actives included acetyl octapeptide-3 alongside other peptides.
- A placebo-patch comparison in 24 healthy adults tested a dissolving microneedle patch containing acetyl octapeptide-3 with other actives.
Mechanism
Like Argireline, SNAP-8 mimics part of the SNAP-25 protein and is proposed to interfere with assembly of the SNARE complex, the machinery that releases neurotransmitter at the nerve–muscle junction. Less signalling is the proposed route to softer expression lines.
Research status
A cosmetic ingredient. Published human studies test it inside multi-ingredient formulas (often Korean microneedle-patch products), so its stand-alone effect is not isolated.
Key studies
The parent peptide: Argireline was designed to interfere with SNARE-complex formation and showed anti-wrinkle activity in an emulsion study.
A synthetic hexapeptide (Argireline) with antiwrinkle activity — Int J Cosmet Sci, 2002 · PMID 18498523
A 12-week clinical study of a hyaluronic-acid microneedle patch whose actives included acetyl octapeptide-3 alongside other peptides.
Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study — J Cosmet Dermatol, 2020 · PMID 31134751
A placebo-patch comparison in 24 healthy adults tested a dissolving microneedle patch containing acetyl octapeptide-3 with other actives.
Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities — Ann Dermatol, 2024 · PMID 39082657
Safety signals in the literature
Patch studies that included it reported good dermal tolerability; systemic data do not exist because it is a topical cosmetic ingredient.
Legal status (South Africa)
Cosmetic-ingredient peptides; research use only in the form we would supply.
Related compounds we stock
Now in the catalogue
SNAP-8 (Acetyl Octapeptide-3) is now in our catalogue as a research vial. Pre-orders are 10% off until the 15 October delivery lands.
Comparisons
Questions
What is SNAP-8 (Acetyl Octapeptide-3)?
An eight-amino-acid extension of Argireline, designed as a topical expression-line peptide that targets the same SNARE complex. Like Argireline, SNAP-8 mimics part of the SNAP-25 protein and is proposed to interfere with assembly of the SNARE complex, the machinery that releases neurotransmitter at the nerve–muscle junction. Less signalling is the proposed route to softer expression lines.
What is the research status of SNAP-8 (Acetyl Octapeptide-3)?
A cosmetic ingredient. Published human studies test it inside multi-ingredient formulas (often Korean microneedle-patch products), so its stand-alone effect is not isolated.
What safety signals are reported for SNAP-8 (Acetyl Octapeptide-3)?
Patch studies that included it reported good dermal tolerability; systemic data do not exist because it is a topical cosmetic ingredient.
Does Living Water Labs stock SNAP-8 (Acetyl Octapeptide-3)?
Not at present. SNAP-8 (Acetyl Octapeptide-3) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Cosmetic-ingredient peptides; research use only in the form we would supply.
Deep dives
More in Skin peptides
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
