Tissue-repair, gut & immune-signalling peptides
Angiotensin-(1-7)
Also known as Ang-(1-7) · Ang 1-7 · TXA127
A heptapeptide of the renin–angiotensin system that tends to counter angiotensin II — the "protective arm" of the ACE2/Ang-(1-7)/Mas axis.
In 60 seconds
Investigational. A phase 1–2 ICU trial reported the infusion as safe, with one serious adverse event (bradycardia) considered possibly related; it showed no significant difference in its phase 2 outcome.
- A major review of the ACE2/angiotensin-(1-7)/Mas axis and its counter-regulatory role in the renin–angiotensin system.
- A phase 1–2 randomised trial in ICU COVID-19 patients found the infusion safe but no significant difference in its phase 2 outcome.
- In a crossover study in mountain bike athletes, oral HPβCD-Ang-(1-7) did not improve time-trial or sprint performance.
Mechanism
ACE2 converts angiotensin II into angiotensin-(1-7), which acts mainly through the Mas receptor. In research models this axis opposes many angiotensin II effects, with vasodilatory, anti-inflammatory and anti-proliferative actions.
Research status
Investigational. Early clinical trials include intravenous infusion in ICU COVID-19 patients and an oral cyclodextrin formulation in athletes; not an approved medicine.
Key studies
A major review of the ACE2/angiotensin-(1-7)/Mas axis and its counter-regulatory role in the renin–angiotensin system.
The ACE2/Angiotensin-(1-7)/MAS Axis of the Renin-Angiotensin System: Focus on Angiotensin-(1-7) — Physiol Rev, 2018 · PMID 29351514
A phase 1–2 randomised trial in ICU COVID-19 patients found the infusion safe but no significant difference in its phase 2 outcome.
Angiotensin-(1-7) infusion in COVID-19 patients admitted to the ICU: a seamless phase 1-2 randomized clinical trial — Ann Intensive Care, 2024 · PMID 39231898
In a crossover study in mountain bike athletes, oral HPβCD-Ang-(1-7) did not improve time-trial or sprint performance.
Effects of oral HPΒCD-angiotensin-(1-7) supplementation on recreational mountain bike athletes: a crossover study — Phys Sportsmed, 2024 · PMID 36752064
Reviews angiotensin-(1-7) in adipose tissue, adipokines and inflammation.
Angiotensin-(1-7), Adipokines and Inflammation — Metabolism, 2019 · PMID 30905634
Safety signals in the literature
A phase 1–2 ICU trial reported the infusion as safe, with one serious adverse event (bradycardia) considered possibly related; it showed no significant difference in its phase 2 outcome.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
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Comparisons
Questions
What is Angiotensin-(1-7)?
A heptapeptide of the renin–angiotensin system that tends to counter angiotensin II — the "protective arm" of the ACE2/Ang-(1-7)/Mas axis. ACE2 converts angiotensin II into angiotensin-(1-7), which acts mainly through the Mas receptor. In research models this axis opposes many angiotensin II effects, with vasodilatory, anti-inflammatory and anti-proliferative actions.
What is the research status of Angiotensin-(1-7)?
Investigational. Early clinical trials include intravenous infusion in ICU COVID-19 patients and an oral cyclodextrin formulation in athletes; not an approved medicine.
What safety signals are reported for Angiotensin-(1-7)?
A phase 1–2 ICU trial reported the infusion as safe, with one serious adverse event (bradycardia) considered possibly related; it showed no significant difference in its phase 2 outcome.
Does Living Water Labs stock Angiotensin-(1-7)?
Not at present. Angiotensin-(1-7) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Repair & immune
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
