Tissue-repair, gut & immune-signalling peptides
Teduglutide
Also known as Gattex · Revestive · GLP-2 analogue
A degradation-resistant analogue of glucagon-like peptide-2 (GLP-2), approved for short bowel syndrome.
In 60 seconds
Approved (EU/US) for short bowel syndrome in adults and children; real-world and paediatric evidence is accumulating. Because it is intestinotrophic, labelling and reviews discuss monitoring for polyp growth; the "double-edged sword" debate centres on this growth effect.
- Reviews teduglutide as a GLP-2 analogue that increases intestinal absorption in short bowel syndrome.
- Describes GLP-2’s role in maintaining the intestinal lining and teduglutide’s clinical data.
- A systematic review of teduglutide in paediatric intestinal failure.
Mechanism
GLP-2 is a gut hormone that promotes growth and maintenance of the intestinal lining. Teduglutide carries a single substitution that slows DPP-4 breakdown, increasing villus height and absorptive capacity.
Research status
Approved (EU/US) for short bowel syndrome in adults and children; real-world and paediatric evidence is accumulating.
Key studies
Reviews teduglutide as a GLP-2 analogue that increases intestinal absorption in short bowel syndrome.
Teduglutide: A Review in Short Bowel Syndrome — Drugs, 2017 · PMID 28194723
Describes GLP-2’s role in maintaining the intestinal lining and teduglutide’s clinical data.
Teduglutide: a review of its use in the treatment of patients with short bowel syndrome — Drugs, 2013 · PMID 23729002
A systematic review of teduglutide in paediatric intestinal failure.
Use of Teduglutide in Children With Intestinal Failure: A Systematic Review — Front Nutr, 2022 · PMID 35774551
A commentary weighing teduglutide’s intestinotrophic benefit against its growth-related risks.
Teduglutide for the treatment of short bowel syndrome: a double-edged sword? — Am J Clin Nutr, 2023 · PMID 37270286
Safety signals in the literature
Because it is intestinotrophic, labelling and reviews discuss monitoring for polyp growth; the "double-edged sword" debate centres on this growth effect.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
Related compounds we stock
Not stocked yet — get notified
Tell us you want Teduglutide and we’ll email you if we add it. Requests decide what we source next.
Not stocked yet
Get notified when we add Teduglutide
One email, only when it reaches the catalogue. Every request is counted when we choose what to stock next.
Comparisons
Questions
What is Teduglutide?
A degradation-resistant analogue of glucagon-like peptide-2 (GLP-2), approved for short bowel syndrome. GLP-2 is a gut hormone that promotes growth and maintenance of the intestinal lining. Teduglutide carries a single substitution that slows DPP-4 breakdown, increasing villus height and absorptive capacity.
What is the research status of Teduglutide?
Approved (EU/US) for short bowel syndrome in adults and children; real-world and paediatric evidence is accumulating.
What safety signals are reported for Teduglutide?
Because it is intestinotrophic, labelling and reviews discuss monitoring for polyp growth; the "double-edged sword" debate centres on this growth effect.
Does Living Water Labs stock Teduglutide?
Not at present. Teduglutide is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Repair & immune
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
