Tissue-repair, gut & immune-signalling peptides
Salmon Calcitonin
Also known as calcitonin · Miacalcic · sCT
A 32-amino-acid thyroid hormone (salmon form) that inhibits bone resorption, used for decades in osteoporosis and Paget’s disease.
In 60 seconds
Registered medicine with declining use; nasal and oral forms were studied extensively. A possible association with cancer led to regulatory restrictions; a review and meta-analysis examined the strength of that signal.
- Reviews salmon calcitonin’s use in metabolic bone diseases over more than 30 years.
- Reviewed the biological rationale and historical data on a postulated calcitonin–cancer association.
- Describes calcitonin lowering serum calcium by reducing bone resorption and renal calcium reabsorption, plus an analgesic action.
Mechanism
Calcitonin acts on osteoclast calcitonin receptors to reduce bone resorption and lowers renal calcium reabsorption; an analgesic effect after vertebral fracture is also described. Salmon calcitonin is more potent than the human form.
Research status
Registered medicine with declining use; nasal and oral forms were studied extensively.
Key studies
Reviews salmon calcitonin’s use in metabolic bone diseases over more than 30 years.
Salmon calcitonin: a review of current and future therapeutic indications — Osteoporos Int, 2008 · PMID 18071651
Reviewed the biological rationale and historical data on a postulated calcitonin–cancer association.
Does salmon calcitonin cause cancer? A review and meta-analysis — Osteoporos Int, 2016 · PMID 26438308
Describes calcitonin lowering serum calcium by reducing bone resorption and renal calcium reabsorption, plus an analgesic action.
Intranasal salmon calcitonin. A review of its pharmacological properties and potential utility in metabolic bone disorders associated with aging — Drugs Aging, 1991 · PMID 1794028
A randomised trial measured pain, bone loss and recovery with intranasal calcitonin after hip fracture.
Randomized, double-blind, clinically controlled trial of intranasal calcitonin treatment in patients with hip fracture — Calcif Tissue Int, 2002 · PMID 12370798
Safety signals in the literature
A possible association with cancer led to regulatory restrictions; a review and meta-analysis examined the strength of that signal.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
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Comparisons
Questions
What is Salmon Calcitonin?
A 32-amino-acid thyroid hormone (salmon form) that inhibits bone resorption, used for decades in osteoporosis and Paget’s disease. Calcitonin acts on osteoclast calcitonin receptors to reduce bone resorption and lowers renal calcium reabsorption; an analgesic effect after vertebral fracture is also described. Salmon calcitonin is more potent than the human form.
What is the research status of Salmon Calcitonin?
Registered medicine with declining use; nasal and oral forms were studied extensively.
What safety signals are reported for Salmon Calcitonin?
A possible association with cancer led to regulatory restrictions; a review and meta-analysis examined the strength of that signal.
Does Living Water Labs stock Salmon Calcitonin?
Not at present. Salmon Calcitonin is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Repair & immune
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
