Incretin & metabolic research compounds
Oxyntomodulin
Also known as OXM
A natural 37-amino-acid gut hormone that activates both the GLP-1 and glucagon receptors — the template for the dual-agonist drug class.
In 60 seconds
Endogenous hormone and research tool; oxyntomodulin-based analogues are in late-stage development. As a short-lived native hormone, research administration has been brief; class effects follow GLP-1/glucagon biology.
- Reviews oxyntomodulin as a dual GLP-1R/GCGR agonist with weight-lowering effects.
- Reviews oxyntomodulin’s dual-agonist pharmacology.
- A 2025 review of oxyntomodulin’s discovery and the analogues it inspired.
Mechanism
Released from intestinal L-cells after meals, oxyntomodulin combines GLP-1-receptor effects (satiety, insulin) with glucagon-receptor effects (energy expenditure). Survodutide and mazdutide are engineered from this idea.
Research status
Endogenous hormone and research tool; oxyntomodulin-based analogues are in late-stage development.
Key studies
Reviews oxyntomodulin as a dual GLP-1R/GCGR agonist with weight-lowering effects.
Action and therapeutic potential of oxyntomodulin — Mol Metab, 2014 · PMID 24749050
Reviews oxyntomodulin’s dual-agonist pharmacology.
Unraveling oxyntomodulin, GLP1’s enigmatic brother — J Endocrinol, 2012 · PMID 23019069
A 2025 review of oxyntomodulin’s discovery and the analogues it inspired.
Oxyntomodulin - past, present and future — Peptides, 2025 · PMID 40187415
Reviews oxyntomodulin-based co-agonist analogues in diabetes and obesity.
Emerging roles of oxyntomodulin-based glucagon-like peptide-1/glucagon co-agonist analogs in diabetes and obesity — Peptides, 2023 · PMID 36669563
Safety signals in the literature
As a short-lived native hormone, research administration has been brief; class effects follow GLP-1/glucagon biology.
Legal status (South Africa)
Approved incretin medicines are prescription-only (scheduled) in South Africa and available only through a prescriber; research-grade material is not a medicine and is not for human use.
Related compounds we stock
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Comparisons
Questions
What is Oxyntomodulin?
A natural 37-amino-acid gut hormone that activates both the GLP-1 and glucagon receptors — the template for the dual-agonist drug class. Released from intestinal L-cells after meals, oxyntomodulin combines GLP-1-receptor effects (satiety, insulin) with glucagon-receptor effects (energy expenditure). Survodutide and mazdutide are engineered from this idea.
What is the research status of Oxyntomodulin?
Endogenous hormone and research tool; oxyntomodulin-based analogues are in late-stage development.
What safety signals are reported for Oxyntomodulin?
As a short-lived native hormone, research administration has been brief; class effects follow GLP-1/glucagon biology.
Does Living Water Labs stock Oxyntomodulin?
Not at present. Oxyntomodulin is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Approved incretin medicines are prescription-only (scheduled) in South Africa and available only through a prescriber; research-grade material is not a medicine and is not for human use.
More in Incretin & metabolic
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
