Sirtuin
Also known as: sirtuins · SIRT1 · NAD-dependent deacetylase
A family of NAD+-dependent enzymes tied to ageing, DNA repair and metabolism — central to NAD+ longevity research.
Sirtuins are a family of enzymes that regulate gene expression, DNA repair and metabolism, and are strongly associated with healthy ageing. Crucially, they depend on NAD+ to function.
That dependence links sirtuins directly to NAD+ and NMN research: because NAD+ declines with age, sirtuin activity is thought to fall with it, which is a core rationale of the longevity and cellular-energy literature.
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RELATED TERMS
NAD+
Nicotinamide adenine dinucleotide — a coenzyme central to mitochondrial energy and sirtuin activity, declining with age.
NMN
Nicotinamide mononucleotide — a direct precursor the body converts into NAD+, studied for cellular energy and longevity.
Mitochondria
The cell’s energy-producing organelles; their function is central to cellular-energy and longevity research.
Autophagy
The cell’s self-cleaning recycling process; enhancing it is a recurring theme in longevity and metabolic research.
Telomere / Telomerase
Protective caps on chromosome ends (telomeres) and the enzyme that extends them (telomerase) — central to longevity research.
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