Growth-hormone secretagogues & GH-axis peptides
ACE-031 (Ramatercept)
Also known as ramatercept · soluble ActRIIB-Fc
A fusion protein of the activin type IIB receptor and an antibody Fc fragment that traps myostatin and related ligands.
In 60 seconds
Trialled in healthy volunteers and boys with Duchenne muscular dystrophy; the Duchenne trial was stopped early. The Duchenne trial was stopped after its second dosing regimen because of potential safety concerns — nosebleeds (epistaxis) and telangiectasias (small dilated blood vessels).
- In 48 healthy postmenopausal women, a single dose was generally well tolerated and the top dose increased lean mass and thigh muscle volume at day 29.
- A randomised trial in ambulatory boys with Duchenne muscular dystrophy reported ACE-031 effects and safety findings.
- Developed gel-based detection of ACE-031 in black-market products, banned under WADA S4.3.
Mechanism
By acting as a decoy receptor, ACE-031 binds myostatin, activin A and other ActRIIB ligands, removing a brake on muscle growth.
Research status
Trialled in healthy volunteers and boys with Duchenne muscular dystrophy; the Duchenne trial was stopped early. Detected in black-market products; WADA-prohibited.
Key studies
In 48 healthy postmenopausal women, a single dose was generally well tolerated and the top dose increased lean mass and thigh muscle volume at day 29.
A single ascending-dose study of muscle regulator ACE-031 in healthy volunteers — Muscle Nerve, 2013 · PMID 23169607
A randomised trial in ambulatory boys with Duchenne muscular dystrophy reported ACE-031 effects and safety findings.
Myostatin inhibitor ACE-031 treatment of ambulatory boys with Duchenne muscular dystrophy: Results of a randomized, placebo-controlled clinical trial — Muscle Nerve, 2017 · PMID 27462804
Developed gel-based detection of ACE-031 in black-market products, banned under WADA S4.3.
Gel Electrophoretic Detection of Black Market ACE-031 — Drug Test Anal, 2025 · PMID 40312924
In marmosets, ACE-031 increased muscle mass and strength.
ACE-031, a soluble activin type IIB receptor, increases muscle mass and strength in the common marmoset (Callithrix jacchus) — PLoS One, 2026 · PMID 41686840
Safety signals in the literature
The Duchenne trial was stopped after its second dosing regimen because of potential safety concerns — nosebleeds (epistaxis) and telangiectasias (small dilated blood vessels).
Legal status (South Africa)
Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
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Comparisons
Questions
What is ACE-031 (Ramatercept)?
A fusion protein of the activin type IIB receptor and an antibody Fc fragment that traps myostatin and related ligands. By acting as a decoy receptor, ACE-031 binds myostatin, activin A and other ActRIIB ligands, removing a brake on muscle growth.
What is the research status of ACE-031 (Ramatercept)?
Trialled in healthy volunteers and boys with Duchenne muscular dystrophy; the Duchenne trial was stopped early. Detected in black-market products; WADA-prohibited.
What safety signals are reported for ACE-031 (Ramatercept)?
The Duchenne trial was stopped after its second dosing regimen because of potential safety concerns — nosebleeds (epistaxis) and telangiectasias (small dilated blood vessels).
Does Living Water Labs stock ACE-031 (Ramatercept)?
Not at present. ACE-031 (Ramatercept) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
More in GH secretagogues
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
