Growth-hormone secretagogues & GH-axis peptides
GHRP-2 (Pralmorelin)
Also known as GHRP 2 · pralmorelin · KP-102
A synthetic hexapeptide growth-hormone-releasing peptide that acts on the ghrelin receptor and is used in some countries as a diagnostic test of GH reserve.
In 60 seconds
Used clinically in Japan as a GH-reserve stimulation test; otherwise unapproved. Diagnostic-test literature reports it as well tolerated in single-dose testing.
- A development profile of pralmorelin, a synthetic growth-hormone-releasing peptide developed by Polygen and Tulane University.
- Evaluated the GHRP-2 stimulation test for diagnosing GH deficiency in patients with hypothalamic-pituitary disorder.
- Developed an LC-MS/MS method to detect GHRP-2 and its metabolite in urine for anti-doping control.
Mechanism
GHRP-2 (D-Ala-D-β-Nal-Ala-Trp-D-Phe-Lys-NH2) is a ghrelin-receptor (GHS-R1a) agonist with no structural homology to GHRH. It stimulates growth-hormone release at both pituitary and hypothalamic level and, like other GHRPs, also raises ACTH/cortisol and prolactin to a degree.
Research status
Used clinically in Japan as a GH-reserve stimulation test; otherwise unapproved. Detected and banned in sport.
Key studies
A development profile of pralmorelin, a synthetic growth-hormone-releasing peptide developed by Polygen and Tulane University.
Pralmorelin: GHRP 2, GPA 748, growth hormone-releasing peptide 2, KP-102 D, KP-102 LN, KP-102D, KP-102LN — Drugs R D, 2004 · PMID 15230633
Evaluated the GHRP-2 stimulation test for diagnosing GH deficiency in patients with hypothalamic-pituitary disorder.
Clinical Usefulness of the Growth Hormone-Releasing Peptide-2 Test for Hypothalamic-Pituitary Disorder — J Endocr Soc, 2022 · PMID 35795807
Developed an LC-MS/MS method to detect GHRP-2 and its metabolite in urine for anti-doping control.
Determination of growth hormone secretagogue pralmorelin (GHRP-2) and its metabolite in human urine by liquid chromatography/electrospray ionization tandem mass spectrometry — Rapid Commun Mass Spectrom, 2010 · PMID 20552695
A review of the GHRP class: synthetic peptides with potent GH-releasing activity acting through receptors distinct from GHRH.
Growth hormone-releasing peptides — Eur J Endocrinol, 1997 · PMID 9186261
Safety signals in the literature
Diagnostic-test literature reports it as well tolerated in single-dose testing. It is not selective: secondary rises in cortisol and prolactin are documented across the GHRP class.
Legal status (South Africa)
Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
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Comparisons
Questions
What is GHRP-2 (Pralmorelin)?
A synthetic hexapeptide growth-hormone-releasing peptide that acts on the ghrelin receptor and is used in some countries as a diagnostic test of GH reserve. GHRP-2 (D-Ala-D-β-Nal-Ala-Trp-D-Phe-Lys-NH2) is a ghrelin-receptor (GHS-R1a) agonist with no structural homology to GHRH. It stimulates growth-hormone release at both pituitary and hypothalamic level and, like other GHRPs, also raises ACTH/cortisol and prolactin to a degree.
What is the research status of GHRP-2 (Pralmorelin)?
Used clinically in Japan as a GH-reserve stimulation test; otherwise unapproved. Detected and banned in sport.
What safety signals are reported for GHRP-2 (Pralmorelin)?
Diagnostic-test literature reports it as well tolerated in single-dose testing. It is not selective: secondary rises in cortisol and prolactin are documented across the GHRP class.
Does Living Water Labs stock GHRP-2 (Pralmorelin)?
Not at present. GHRP-2 (Pralmorelin) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
More in GH secretagogues
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
