Growth-hormone secretagogues & GH-axis peptides
Hexarelin
Also known as examorelin
A potent synthetic growth-hormone-releasing hexapeptide with additional, receptor-mediated actions studied in cardiovascular models.
In 60 seconds
Preclinical and small human studies; not an approved medicine. Like other GHRPs it can raise cortisol and prolactin; attenuation of the GH response with repeated exposure has been reported.
- Reviews evidence that hexarelin, via peripheral GHSR in heart and vessels, may have direct cardiovascular effects.
- A review of GH secretagogues weighing their reported effects against the limited long-term safety evidence.
- In an ischaemia-reperfusion kidney-injury model, hexarelin reduced apoptosis via the MDM2/p53 pathway.
Mechanism
Hexarelin activates the ghrelin receptor (GHSR) and releases GH. Research also describes direct cardiovascular actions through GHSR and the scavenger receptor CD36 in heart and vessel tissue, independent of GH.
Research status
Preclinical and small human studies; not an approved medicine.
Key studies
Reviews evidence that hexarelin, via peripheral GHSR in heart and vessels, may have direct cardiovascular effects.
The cardiovascular action of hexarelin — J Geriatr Cardiol, 2014 · PMID 25278975
A review of GH secretagogues weighing their reported effects against the limited long-term safety evidence.
The Safety and Efficacy of Growth Hormone Secretagogues — Sex Med Rev, 2018 · PMID 28400207
In an ischaemia-reperfusion kidney-injury model, hexarelin reduced apoptosis via the MDM2/p53 pathway.
Hexarelin alleviates apoptosis on ischemic acute kidney injury via MDM2/p53 pathway — Eur J Med Res, 2023 · PMID 37710348
In a mouse aneurysm model, hexarelin reduced aneurysm formation and smooth-muscle phenotype switching.
Hexarelin attenuates abdominal aortic aneurysm formation by inhibiting SMC phenotype switch and inflammasome activation — Microvasc Res, 2022 · PMID 34856183
Safety signals in the literature
Like other GHRPs it can raise cortisol and prolactin; attenuation of the GH response with repeated exposure has been reported. No long-term human safety data.
Legal status (South Africa)
Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
Related compounds we stock
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Comparisons
Questions
What is Hexarelin?
A potent synthetic growth-hormone-releasing hexapeptide with additional, receptor-mediated actions studied in cardiovascular models. Hexarelin activates the ghrelin receptor (GHSR) and releases GH. Research also describes direct cardiovascular actions through GHSR and the scavenger receptor CD36 in heart and vessel tissue, independent of GH.
What is the research status of Hexarelin?
Preclinical and small human studies; not an approved medicine.
What safety signals are reported for Hexarelin?
Like other GHRPs it can raise cortisol and prolactin; attenuation of the GH response with repeated exposure has been reported. No long-term human safety data.
Does Living Water Labs stock Hexarelin?
Not at present. Hexarelin is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
More in GH secretagogues
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
