Incretin & metabolic research compounds
Adipotide (FTPP)
Also known as prohibitin-targeting peptide · CKGGRAKDC-GG-D(KLAKLAK)2
A peptidomimetic that targets prohibitin on the blood vessels of white fat and triggers their apoptosis, studied in obese monkeys.
In 60 seconds
Primate study published in 2011; no human efficacy trials reported. Published data are limited to animal work; there is no human safety data.
- In obese monkeys, adipotide caused weight loss and improved insulin resistance by targeting white-fat vasculature.
- A comment argued the weight loss may reflect a direct effect on food consumption.
- Compared anti-angiogenic nanoparticle and bioconjugate approaches to targeting fat vasculature.
Mechanism
Adipotide pairs a fat-vasculature homing motif with a pro-apoptotic sequence; cutting off the blood supply of white adipose tissue reduced fat mass in animals. A published comment suggested reduced food intake may explain part of the effect.
Research status
Primate study published in 2011; no human efficacy trials reported.
Key studies
In obese monkeys, adipotide caused weight loss and improved insulin resistance by targeting white-fat vasculature.
A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys — Sci Transl Med, 2011 · PMID 22072637
A comment argued the weight loss may reflect a direct effect on food consumption.
Comment on "a peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys" — Sci Transl Med, 2012 · PMID 22539771
Compared anti-angiogenic nanoparticle and bioconjugate approaches to targeting fat vasculature.
A comparative study between nanoparticle-targeted therapeutics and bioconjugates as obesity medication — J Control Release, 2013 · PMID 23871959
Safety signals in the literature
Published data are limited to animal work; there is no human safety data.
Legal status (South Africa)
Approved incretin medicines are prescription-only (scheduled) in South Africa and available only through a prescriber; research-grade material is not a medicine and is not for human use.
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Comparisons
Questions
What is Adipotide (FTPP)?
A peptidomimetic that targets prohibitin on the blood vessels of white fat and triggers their apoptosis, studied in obese monkeys. Adipotide pairs a fat-vasculature homing motif with a pro-apoptotic sequence; cutting off the blood supply of white adipose tissue reduced fat mass in animals. A published comment suggested reduced food intake may explain part of the effect.
What is the research status of Adipotide (FTPP)?
Primate study published in 2011; no human efficacy trials reported.
What safety signals are reported for Adipotide (FTPP)?
Published data are limited to animal work; there is no human safety data.
Does Living Water Labs stock Adipotide (FTPP)?
Not at present. Adipotide (FTPP) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Approved incretin medicines are prescription-only (scheduled) in South Africa and available only through a prescriber; research-grade material is not a medicine and is not for human use.
More in Incretin & metabolic
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
