Int J Cosmet Sci · 2002
A synthetic hexapeptide (Argireline) with antiwrinkle activity
Describes the design of the parent SNARE-complex-inhibiting peptide, argireline, and its anti-wrinkle activity.
View on PubMed (PMID 18498523)◂ RESEARCH LIBRARY
Research Overview
SNAP-8
Ac-EEMQRRAD-NH2 (acetyl octapeptide-3)
CoA on requestPurity CoAResearch use only
In 60 seconds
SNAP-8 (acetyl octapeptide-3) is an octapeptide extension of argireline (acetyl hexapeptide-3).
- Describes the design of the parent SNARE-complex-inhibiting peptide, argireline, and its anti-wrinkle activity.
- A clinical study of a dissolving microneedle patch containing acetyl octapeptide-3 evaluated wrinkle measures and safety.
- A 12-week monocentric study of hyaluronic-acid microneedle patches carrying peptides including acetyl octapeptide-3.
OVERVIEW
SNAP-8 (Ac-EEMQRRAD-NH2 (acetyl octapeptide-3)) is a research-grade peptide supplied by Living Water Labs for laboratory investigation. Acetyl octapeptide-3, a SNARE-complex research peptide — 10 mg lyophilised powder per vial.. Each published certificate is an independent Janoshik Analytical report naming the compound and its HPLC purity; certificates not yet published can be requested. The summary below outlines documented mechanisms and study areas reported in the research literature.
Scientific name
Ac-EEMQRRAD-NH2 (acetyl octapeptide-3)
Molecular weight
1075.2 g/mol
Vial size
10mg
DOCUMENTED RESEARCH AREAS
- ▸Octapeptide extension of argireline (acetyl hexapeptide-3)
- ▸Patterned on SNAP-25 to compete within the SNARE complex
- ▸Studied as a topical expression-line ingredient
- ▸Delivered by hyaluronic-acid microneedle patches in recent clinical research
- ▸10 mg lyophilised vial — laboratory research use only
MECHANISM OF ACTION
SNAP-8 (acetyl octapeptide-3) is an octapeptide extension of argireline (acetyl hexapeptide-3). Both are patterned on the N-terminus of SNAP-25 and designed to compete for a place in the SNARE complex, the machinery that releases neurotransmitter at the neuromuscular junction; reduced vesicle release is the proposed basis of their study as topical expression-line ingredients.
- ▸Patterned on the N-terminus of SNAP-25
- ▸Competes within the SNARE vesicle-release complex
- ▸Studied topically, including microneedle delivery to overcome poor skin penetration
STUDY SUMMARIES
3 peer-reviewed referencesAnn Dermatol · 2024
Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities
A clinical study of a dissolving microneedle patch containing acetyl octapeptide-3 evaluated wrinkle measures and safety.
View on PubMed (PMID 39082657)J Cosmet Dermatol · 2020
Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study
A 12-week monocentric study of hyaluronic-acid microneedle patches carrying peptides including acetyl octapeptide-3.
View on PubMed (PMID 31134751)CITATIONS
- 1.A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002. PMID 18498523. pubmed.ncbi.nlm.nih.gov/18498523
- 2.Clinical Safety and Efficacy Evaluation of a Dissolving Microneedle Patch Having Dual Anti-Wrinkle Effects With Safe and Long-Term Activities. Ann Dermatol. 2024. PMID 39082657. pubmed.ncbi.nlm.nih.gov/39082657
- 3.Efficacy of bioactive peptides loaded on hyaluronic acid microneedle patches: A monocentric clinical study. J Cosmet Dermatol. 2020. PMID 31134751. pubmed.ncbi.nlm.nih.gov/31134751
Citations describe findings reported in the referenced preclinical, in-vitro or clinical literature. They are provided for research and educational purposes only and are not a therapeutic claim.
All information is provided for research and educational purposes only and describes findings in preclinical/in-vitro literature. Not medical advice. Products are supplied strictly for research purposes — not for human consumption.
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How-To Research Guides
Step-by-step guides — reconstitution, dosing, storage, handling and CoAs.
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Work out exact bacteriostatic-water volumes for any vial — a free lab tool.
Explore →Compound Research Library
Per-compound overviews: documented mechanisms, study areas and cited literature.
Explore →Purity CoAs
Independent Janoshik Analytical certificates — compound identity and HPLC purity — published as styled summaries, the rest on request.
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Purity, CoAs, storage, shipping and ordering — answered.
Explore →PEPTIDE GLOSSARY
Certificate of Analysis (CoA)
Third-party lab documentation confirming a batch’s identity and purity.
Explore →HPLC Verification
High-performance liquid chromatography — the assay behind the purity figure on every published certificate.
Explore →Reconstitution
Dissolving a lyophilised peptide in bacteriostatic water to a target concentration.
Explore →Lyophilised
Freeze-dried to a stable powder for cold, dark, long-term storage.
Explore →Bacteriostatic Water
Sterile water with 0.9% benzyl alcohol, used to reconstitute peptides.
Explore →Research Use Only
Supplied strictly for laboratory research — not for human consumption.
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