Tissue-repair, gut & immune-signalling peptides
Thymopentin (TP-5)
Also known as TP-5 · thymopoietin pentapeptide · Arg-Lys-Asp-Val-Tyr
A synthetic pentapeptide matching the active site (residues 32–36) of the thymic hormone thymopoietin, studied as an immunomodulator.
In 60 seconds
Registered in some countries historically; mostly 1980s–90s clinical research, with renewed interest in hybrid peptides. A 1985 overview of its preclinical safety programme reported a favourable profile.
- Describes thymopentin as the active-site pentapeptide (residues 32–36) of thymopoietin.
- A double-blind study of 18 patients measured clinical and lymphocyte changes with TP-5 in atopic dermatitis.
- Reviews the status of thymopentin and splenopentin as immunomodulating peptides.
Mechanism
Thymopentin reproduces thymopoietin’s activity on T-cell differentiation and immune balance; it was investigated in atopic dermatitis, rheumatoid arthritis and immunodeficiency in the 1980s.
Research status
Registered in some countries historically; mostly 1980s–90s clinical research, with renewed interest in hybrid peptides.
Key studies
Describes thymopentin as the active-site pentapeptide (residues 32–36) of thymopoietin.
Thymopoietin to thymopentin: experimental studies — Surv Immunol Res, 1985 · PMID 2994196
A double-blind study of 18 patients measured clinical and lymphocyte changes with TP-5 in atopic dermatitis.
Thymopoietin pentapeptide (TP-5) improves clinical parameters and lymphocyte subpopulations in atopic dermatitis — J Am Acad Dermatol, 1983 · PMID 6339571
Reviews the status of thymopentin and splenopentin as immunomodulating peptides.
Thymopentin and splenopentin as immunomodulators. Current status — Immunol Res, 1998 · PMID 9638477
Summarises the preclinical safety programme for thymopentin.
Thymopentin: safety overview — Surv Immunol Res, 1985 · PMID 3898287
Safety signals in the literature
A 1985 overview of its preclinical safety programme reported a favourable profile.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
Related compounds we stock
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Comparisons
Questions
What is Thymopentin (TP-5)?
A synthetic pentapeptide matching the active site (residues 32–36) of the thymic hormone thymopoietin, studied as an immunomodulator. Thymopentin reproduces thymopoietin’s activity on T-cell differentiation and immune balance; it was investigated in atopic dermatitis, rheumatoid arthritis and immunodeficiency in the 1980s.
What is the research status of Thymopentin (TP-5)?
Registered in some countries historically; mostly 1980s–90s clinical research, with renewed interest in hybrid peptides.
What safety signals are reported for Thymopentin (TP-5)?
A 1985 overview of its preclinical safety programme reported a favourable profile.
Does Living Water Labs stock Thymopentin (TP-5)?
Not at present. Thymopentin (TP-5) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Repair & immune
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
