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KPV research peptide

Research Overview

KPV

Calm, Repair, Recover

HPLC-verified 98%Batch CoAResearch use only

OVERVIEW

KPV (Calm, Repair, Recover) is a research-grade peptide supplied by Living Water Labs for laboratory investigation. Powerful anti-inflammatory that calms the gut and balances immunity. Each batch is HPLC-verified to a minimum 98% purity with a batch-specific Certificate of Analysis. The summary below outlines documented mechanisms and study areas reported in the research literature.

Scientific name

Lys-Pro-Val (alpha-MSH C-terminal Tripeptide)

Molecular weight

341.4 g/mol

Purity

99.1%

Vial size

10mg

DOCUMENTED RESEARCH AREAS

  • ▸Powerful anti-inflammatory action
  • ▸Calms gut inflammation
  • ▸Balances immune response
  • ▸Eases flare-ups and swelling
  • ▸Soothes skin irritation
  • ▸Works oral or injectable

MECHANISM OF ACTION

KPV is the C-terminal tripeptide (Lys-Pro-Val) of alpha-melanocyte-stimulating hormone. Laboratory studies report that it is taken up by cells via the PepT1 transporter and dampens pro-inflammatory NF-kB signalling, reducing inflammatory markers in cell and rodent models of intestinal inflammation.

  • ▸Enters cells via the PepT1 di/tri-peptide transporter
  • ▸Inhibits NF-kB pro-inflammatory signalling in intestinal cell models
  • ▸Reduces inflammatory markers in rodent colitis models

STUDY SUMMARIES

4 peer-reviewed references

Gastroenterology · 2008

PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation

PepT1-mediated uptake of KPV reduced intestinal inflammation and pro-inflammatory signalling in cell and mouse models.

View on PubMed (PMID 18061177)

Inflamm Bowel Dis · 2008

Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease

KPV showed anti-inflammatory activity in murine models of inflammatory bowel disease.

View on PubMed (PMID 18092346)

Cell Mol Gastroenterol Hepatol · 2016

Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of anti-inflammatory tripeptide KPV

In colitis-associated cancer models, KPV delivered via PepT1 reduced inflammation-driven tumour development.

View on PubMed (PMID 27458604)

Mol Ther · 2017

Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis

Orally delivered KPV nanoparticles reduced disease markers in a mouse model of ulcerative colitis.

View on PubMed (PMID 28143741)

CITATIONS

  1. 1.PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008. PMID 18061177. pubmed.ncbi.nlm.nih.gov/18061177
  2. 2.Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of inflammatory bowel disease. Inflamm Bowel Dis. 2008. PMID 18092346. pubmed.ncbi.nlm.nih.gov/18092346
  3. 3.Critical role of PepT1 in promoting colitis-associated cancer and therapeutic benefits of anti-inflammatory tripeptide KPV. Cell Mol Gastroenterol Hepatol. 2016. PMID 27458604. pubmed.ncbi.nlm.nih.gov/27458604
  4. 4.Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles Efficiently Alleviates Ulcerative Colitis. Mol Ther. 2017. PMID 28143741. pubmed.ncbi.nlm.nih.gov/28143741

Citations describe findings reported in the referenced preclinical, in-vitro or clinical literature. They are provided for research and educational purposes only and are not a therapeutic claim.

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All information is provided for research and educational purposes only and describes findings in preclinical/in-vitro literature. Not medical advice. Products are supplied strictly for research purposes — not for human consumption.

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