Nootropic & neuropeptide research compounds
Desmopressin (DDAVP)
Also known as DDAVP · 1-deamino-8-D-arginine vasopressin
A synthetic vasopressin analogue selective for the V2 receptor — strongly antidiuretic, with little effect on blood pressure.
In 60 seconds
Registered medicine for central diabetes insipidus, nocturnal enuresis and mild bleeding disorders; also used as a diagnostic test in Cushing’s syndrome. Hyponatraemia (water intoxication) is the key documented risk.
- Describes desmopressin’s enhanced antidiuretic potency, reduced pressor activity and longer action than vasopressin.
- Reviews hyponatraemia as a complication of intranasal desmopressin.
- Reviews desmopressin’s haemostatic use in haemophilia A and von Willebrand disease.
Mechanism
Two modifications (deamination at position 1, D-arginine at 8) make desmopressin longer-acting and V2-selective. In the kidney it concentrates urine; on endothelium it releases von Willebrand factor and factor VIII.
Research status
Registered medicine for central diabetes insipidus, nocturnal enuresis and mild bleeding disorders; also used as a diagnostic test in Cushing’s syndrome.
Key studies
Describes desmopressin’s enhanced antidiuretic potency, reduced pressor activity and longer action than vasopressin.
Desmopressin — Ann Intern Med, 1985 · PMID 3893256
Reviews hyponatraemia as a complication of intranasal desmopressin.
Intranasal desmopressin-induced hyponatremia — Pharmacotherapy, 1996 · PMID 8700794
Reviews desmopressin’s haemostatic use in haemophilia A and von Willebrand disease.
A Review of Desmopressin Use in Bleeding Disorders: An Unsung Hero? — Biomolecules, 2025 · PMID 40723839
Simulated why desmopressin binds the V2 receptor selectively over V1a and oxytocin receptors.
Investigation of mechanism of desmopressin binding in vasopressin V2 receptor versus vasopressin V1a and oxytocin receptors: molecular dynamics simulation of the agonist-bound state in the membrane-aqueous system — Biopolymers, 2006 · PMID 16333859
Safety signals in the literature
Hyponatraemia (water intoxication) is the key documented risk.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
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Comparisons
Questions
What is Desmopressin (DDAVP)?
A synthetic vasopressin analogue selective for the V2 receptor — strongly antidiuretic, with little effect on blood pressure. Two modifications (deamination at position 1, D-arginine at 8) make desmopressin longer-acting and V2-selective. In the kidney it concentrates urine; on endothelium it releases von Willebrand factor and factor VIII.
What is the research status of Desmopressin (DDAVP)?
Registered medicine for central diabetes insipidus, nocturnal enuresis and mild bleeding disorders; also used as a diagnostic test in Cushing’s syndrome.
What safety signals are reported for Desmopressin (DDAVP)?
Hyponatraemia (water intoxication) is the key documented risk.
Does Living Water Labs stock Desmopressin (DDAVP)?
Not at present. Desmopressin (DDAVP) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Nootropic & neuro
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
