Nootropic & neuropeptide research compounds
P021 (Peptide 021)
Also known as P021 · Peptide 6 · CNTF mimetic peptide
A tetrapeptide derived from the most active region of ciliary neurotrophic factor (CNTF), studied for neurogenesis and synaptic plasticity.
In 60 seconds
Preclinical (ageing, Alzheimer’s, traumatic brain injury and CDKL5 models). No human safety data.
- An 11-mer CNTF-derived peptide enhanced neurogenesis, synaptic plasticity and memory in mice.
- In an Alzheimer’s mouse model, P021 prevented dendritic and synaptic deficits and cognitive impairment.
- In aged rats, the compound rescued cognitive decline associated with ageing.
Mechanism
Neurotrophic factors cannot cross the blood–brain barrier and have short half-lives. P021 (derived from the 11-mer Peptide 6) is a small CNTF-region mimetic reported to enhance dentate-gyrus neurogenesis and synaptic markers in rodents.
Research status
Preclinical (ageing, Alzheimer’s, traumatic brain injury and CDKL5 models). No human studies.
Key studies
An 11-mer CNTF-derived peptide enhanced neurogenesis, synaptic plasticity and memory in mice.
Enhancement of dentate gyrus neurogenesis, dendritic and synaptic plasticity and memory by a neurotrophic peptide — Neurobiol Aging, 2011 · PMID 19767127
In an Alzheimer’s mouse model, P021 prevented dendritic and synaptic deficits and cognitive impairment.
Prevention of dendritic and synaptic deficits and cognitive impairment with a neurotrophic compound — Alzheimers Res Ther, 2017 · PMID 28655344
In aged rats, the compound rescued cognitive decline associated with ageing.
Rescue of cognitive-aging by administration of a neurogenic and/or neurotrophic compound — Neurobiol Aging, 2014 · PMID 24702821
In a TBI model, Peptide 6 enhanced neurogenesis and memory.
Enhancement of neurogenesis and memory by a neurotrophic peptide in mild to moderate traumatic brain injury — Neurosurgery, 2015 · PMID 25255260
Safety signals in the literature
No human safety data.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
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Comparisons
Questions
What is P021 (Peptide 021)?
A tetrapeptide derived from the most active region of ciliary neurotrophic factor (CNTF), studied for neurogenesis and synaptic plasticity. Neurotrophic factors cannot cross the blood–brain barrier and have short half-lives. P021 (derived from the 11-mer Peptide 6) is a small CNTF-region mimetic reported to enhance dentate-gyrus neurogenesis and synaptic markers in rodents.
What is the research status of P021 (Peptide 021)?
Preclinical (ageing, Alzheimer’s, traumatic brain injury and CDKL5 models). No human studies.
What safety signals are reported for P021 (Peptide 021)?
No human safety data.
Does Living Water Labs stock P021 (Peptide 021)?
Not at present. P021 (Peptide 021) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Nootropic & neuro
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
