Nootropic & neuropeptide research compounds
Noopept (Omberacetam)
Also known as omberacetam · GVS-111 · N-phenylacetyl-L-prolylglycine ethyl ester
A proline-containing dipeptide nootropic developed in Russia as a piracetam analogue, whose metabolite resembles an endogenous neuropeptide.
In 60 seconds
Registered as a medicine in Russia; unapproved elsewhere. Human data are limited to Russian clinical use; an FDA-related analysis found it among unapproved drugs in supplements, raising quality and dose concerns.
- Identified noopept’s main brain metabolite as resembling the endogenous peptide cyclo-L-prolylglycine.
- In a rat photochemical-stroke model, GVS-111 restored memory measures and was neuroprotective.
- Found omberacetam and other unapproved drugs in over-the-counter cognitive supplements.
Mechanism
Noopept is metabolised to cyclo-L-prolylglycine, an endogenous cyclic dipeptide. Preclinical work reports neuroprotective and memory-related effects in stroke and diabetes models.
Research status
Registered as a medicine in Russia; unapproved elsewhere. It has been found as an undeclared ingredient in US "cognitive" supplements.
Key studies
Identified noopept’s main brain metabolite as resembling the endogenous peptide cyclo-L-prolylglycine.
The major metabolite of dipeptide piracetam analogue GVS-111 in rat brain and its similarity to endogenous neuropeptide cyclo-L-prolylglycine — Eur J Drug Metab Pharmacokinet, 1997 · PMID 9358206
In a rat photochemical-stroke model, GVS-111 restored memory measures and was neuroprotective.
Memory restoring and neuroprotective effects of the proline-containing dipeptide, GVS-111, in a photochemical stroke model — Behav Pharmacol, 1999 · PMID 10780261
Found omberacetam and other unapproved drugs in over-the-counter cognitive supplements.
Five Unapproved Drugs Found in Cognitive Enhancement Supplements — Neurol Clin Pract, 2021 · PMID 34484905
Characterised noopept’s physicochemical and structural properties as an API.
Physicochemical and structural analysis of N-phenylacetyl-L-prolylglycine ethyl ester (Noopept) - An active pharmaceutical ingredient with nootropic activity — J Pharm Biomed Anal, 2025 · PMID 39298839
Safety signals in the literature
Human data are limited to Russian clinical use; an FDA-related analysis found it among unapproved drugs in supplements, raising quality and dose concerns.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
Related compounds we stock
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Comparisons
Questions
What is Noopept (Omberacetam)?
A proline-containing dipeptide nootropic developed in Russia as a piracetam analogue, whose metabolite resembles an endogenous neuropeptide. Noopept is metabolised to cyclo-L-prolylglycine, an endogenous cyclic dipeptide. Preclinical work reports neuroprotective and memory-related effects in stroke and diabetes models.
What is the research status of Noopept (Omberacetam)?
Registered as a medicine in Russia; unapproved elsewhere. It has been found as an undeclared ingredient in US "cognitive" supplements.
What safety signals are reported for Noopept (Omberacetam)?
Human data are limited to Russian clinical use; an FDA-related analysis found it among unapproved drugs in supplements, raising quality and dose concerns.
Does Living Water Labs stock Noopept (Omberacetam)?
Not at present. Noopept (Omberacetam) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Nootropic & neuro
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
