Nootropic & neuropeptide research compounds
Dihexa
Also known as PNB-0408 · N-hexanoic-Tyr-Ile-(6) aminohexanoic amide
A small, blood–brain-barrier-permeable angiotensin IV analogue reported to act through the hepatocyte growth factor (HGF)/c-Met system.
In 60 seconds
Preclinical only (rodent cognitive and neurodegeneration models, hair-cell protection, nerve repair). No human safety data.
- Reported that the pro-cognitive and synaptogenic effects of AngIV-derived peptides including dihexa depend on HGF/c-Met activation.
- In APP/PS1 Alzheimer’s mice, dihexa improved cognitive measures via the PI3K/AKT pathway.
- Reviews the design of small-molecule AngIV analogues for neurodegenerative disease models.
Mechanism
Dihexa was developed from angiotensin IV-related peptides with pro-cognitive effects. Its developers report that it potentiates HGF signalling at the c-Met receptor, promoting synapse formation (synaptogenesis) in hippocampal neurons.
Research status
Preclinical only (rodent cognitive and neurodegeneration models, hair-cell protection, nerve repair). No human trials published.
Key studies
Reported that the pro-cognitive and synaptogenic effects of AngIV-derived peptides including dihexa depend on HGF/c-Met activation.
The procognitive and synaptogenic effects of angiotensin IV-derived peptides are dependent on activation of the hepatocyte growth factor/c-met system — J Pharmacol Exp Ther, 2014 · PMID 25187433
In APP/PS1 Alzheimer’s mice, dihexa improved cognitive measures via the PI3K/AKT pathway.
AngIV-Analog Dihexa Rescues Cognitive Impairment and Recovers Memory in the APP/PS1 Mouse via the PI3K/AKT Signaling Pathway — Brain Sci, 2021 · PMID 34827486
Reviews the design of small-molecule AngIV analogues for neurodegenerative disease models.
The development of small molecule angiotensin IV analogs to treat Alzheimer’s and Parkinson’s diseases — Prog Neurobiol, 2015 · PMID 25455861
In zebrafish, dihexa protected sensory hair cells from aminoglycoside damage.
Hepatocyte growth factor mimetic protects lateral line hair cells from aminoglycoside exposure — Front Cell Neurosci, 2015 · PMID 25674052
Safety signals in the literature
No human safety data. Because HGF/c-Met is also an oncogenic pathway, long-term activation is a theoretical concern raised in the field.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
Related compounds we stock
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Comparisons
Questions
What is Dihexa?
A small, blood–brain-barrier-permeable angiotensin IV analogue reported to act through the hepatocyte growth factor (HGF)/c-Met system. Dihexa was developed from angiotensin IV-related peptides with pro-cognitive effects. Its developers report that it potentiates HGF signalling at the c-Met receptor, promoting synapse formation (synaptogenesis) in hippocampal neurons.
What is the research status of Dihexa?
Preclinical only (rodent cognitive and neurodegeneration models, hair-cell protection, nerve repair). No human trials published.
What safety signals are reported for Dihexa?
No human safety data. Because HGF/c-Met is also an oncogenic pathway, long-term activation is a theoretical concern raised in the field.
Does Living Water Labs stock Dihexa?
Not at present. Dihexa is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Nootropic & neuro
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
