Nootropic & neuropeptide research compounds
DSIP (Delta Sleep-Inducing Peptide)
Also known as delta sleep-inducing peptide · emideltide
A nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) isolated in 1977 from rabbit cerebral venous blood during studies of sleep.
In 60 seconds
Studied in the 1980s in small human sleep studies; no approved medicine and little modern research. Older small studies reported no major issues; data are too limited to characterise safety.
- The isolation paper: a peptide enhancing delta EEG after brain infusion in rabbits, with its amino-acid sequence.
- Concludes that DSIP’s link to sleep was never further characterised and its receptor remains unknown.
- Double-blind studies in insomniacs examined single and repeated DSIP doses on night sleep and waking function.
Mechanism
DSIP was named for enhancing slow-wave (delta) EEG activity after brain infusion in rabbits. Its receptor and gene have never been identified, and its link to sleep has not been firmly established — reviews call it an unresolved riddle.
Research status
Studied in the 1980s in small human sleep studies; no approved medicine and little modern research.
Key studies
The isolation paper: a peptide enhancing delta EEG after brain infusion in rabbits, with its amino-acid sequence.
Characterization of a delta-electroencephalogram (-sleep)-inducing peptide — Proc Natl Acad Sci U S A, 1977 · PMID 265572
Concludes that DSIP’s link to sleep was never further characterised and its receptor remains unknown.
Delta sleep-inducing peptide (DSIP): a still unresolved riddle — J Neurochem, 2006 · PMID 16539679
Double-blind studies in insomniacs examined single and repeated DSIP doses on night sleep and waking function.
DSIP in sleep disturbances — Eur Neurol, 1986 · PMID 3758119
An early review of DSIP isolation, characterisation and sleep/extra-sleep effects.
Delta-sleep-inducing peptide (DSIP): a review — Neurosci Biobehav Rev, 1984 · PMID 6145137
Safety signals in the literature
Older small studies reported no major issues; data are too limited to characterise safety.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
Related compounds we stock
Now in the catalogue
DSIP (Delta Sleep-Inducing Peptide) is now in our catalogue as a research vial. Pre-orders are 10% off until the 15 October delivery lands.
Comparisons
Questions
What is DSIP (Delta Sleep-Inducing Peptide)?
A nonapeptide (Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu) isolated in 1977 from rabbit cerebral venous blood during studies of sleep. DSIP was named for enhancing slow-wave (delta) EEG activity after brain infusion in rabbits. Its receptor and gene have never been identified, and its link to sleep has not been firmly established — reviews call it an unresolved riddle.
What is the research status of DSIP (Delta Sleep-Inducing Peptide)?
Studied in the 1980s in small human sleep studies; no approved medicine and little modern research.
What safety signals are reported for DSIP (Delta Sleep-Inducing Peptide)?
Older small studies reported no major issues; data are too limited to characterise safety.
Does Living Water Labs stock DSIP (Delta Sleep-Inducing Peptide)?
Not at present. DSIP (Delta Sleep-Inducing Peptide) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
Deep dives
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Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
