Tissue-repair, gut & immune-signalling peptides
GLP-2 (Glucagon-Like Peptide-2)
Also known as glucagon-like peptide 2
A 33-amino-acid gut hormone co-secreted with GLP-1 that drives growth and repair of the intestinal lining.
In 60 seconds
Endogenous hormone and research target; the degradation-resistant analogue teduglutide is an approved medicine. Because GLP-2 is intestinotrophic, its relationship with neoplasia has been systematically reviewed.
- Describes GLP-2 as a 33-amino-acid proglucagon product promoting nutrient absorption.
- Reviews GLP-2’s effects on intestinal growth, absorption, barrier function and repair.
- A systematic review of evidence on GLP-2 and neoplasia.
Mechanism
GLP-2 is encoded next to GLP-1 in the proglucagon gene and released from intestinal L-cells after meals. Through its receptor it stimulates crypt-cell proliferation, intestinal blood flow, nutrient absorption and barrier function.
Research status
Endogenous hormone and research target; the degradation-resistant analogue teduglutide is an approved medicine.
Key studies
Describes GLP-2 as a 33-amino-acid proglucagon product promoting nutrient absorption.
Glucagon-like peptide 2 — J Clin Endocrinol Metab, 2001 · PMID 11297614
Reviews GLP-2’s effects on intestinal growth, absorption, barrier function and repair.
Glucagon-like Peptide-2 and the Regulation of Intestinal Growth and Function — Compr Physiol, 2018 · PMID 29978894
A systematic review of evidence on GLP-2 and neoplasia.
Glucagon like peptide-2 and neoplasia; a systematic review — Expert Rev Gastroenterol Hepatol, 2018 · PMID 29231791
Studied a GLP-1/GLP-2 dual agonist targeting the gut–liver axis in NASH models.
A GLP-1/GLP-2 receptor dual agonist to treat NASH: Targeting the gut-liver axis and microbiome — Hepatology, 2022 · PMID 34773257
Safety signals in the literature
Because GLP-2 is intestinotrophic, its relationship with neoplasia has been systematically reviewed.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
Related compounds we stock
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Comparisons
Questions
What is GLP-2 (Glucagon-Like Peptide-2)?
A 33-amino-acid gut hormone co-secreted with GLP-1 that drives growth and repair of the intestinal lining. GLP-2 is encoded next to GLP-1 in the proglucagon gene and released from intestinal L-cells after meals. Through its receptor it stimulates crypt-cell proliferation, intestinal blood flow, nutrient absorption and barrier function.
What is the research status of GLP-2 (Glucagon-Like Peptide-2)?
Endogenous hormone and research target; the degradation-resistant analogue teduglutide is an approved medicine.
What safety signals are reported for GLP-2 (Glucagon-Like Peptide-2)?
Because GLP-2 is intestinotrophic, its relationship with neoplasia has been systematically reviewed.
Does Living Water Labs stock GLP-2 (Glucagon-Like Peptide-2)?
Not at present. GLP-2 (Glucagon-Like Peptide-2) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Repair & immune
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
