Growth-hormone secretagogues & GH-axis peptides
MGF (Mechano Growth Factor)
Also known as IGF-1Ec · IGF-IEc · PEG-MGF · mechano-growth factor
A splice variant of the IGF-1 gene (IGF-IEc) produced in response to mechanical load, with a distinct E-domain peptide studied in tissue repair.
In 60 seconds
Cell and animal research only; synthetic "MGF" peptides sold online are E-domain fragments with no clinical development. No human safety data.
- Reviews how mechanical stress regulates IGF-I splice isoforms and the evidence for an MGF role in repair.
- Reviews MGF as a mechanically sensitive growth factor highly expressed in chondrocytes.
- In mechanically injured human ACL fibroblasts, MGF improved cell mobility via Rac1 and RhoA pathways.
Mechanism
Alternative splicing of IGF-1 exons yields the IGF-IEc isoform, up-regulated by mechanical stress in muscle, bone, tendon and cartilage. Its unique E-domain peptide is studied for effects on progenitor-cell proliferation separate from mature IGF-1.
Research status
Cell and animal research only; synthetic "MGF" peptides sold online are E-domain fragments with no clinical development.
Key studies
Reviews how mechanical stress regulates IGF-I splice isoforms and the evidence for an MGF role in repair.
Minireview: Mechano-growth factor: a putative product of IGF-I gene expression involved in tissue repair and regeneration — Endocrinology, 2010 · PMID 20130113
Reviews MGF as a mechanically sensitive growth factor highly expressed in chondrocytes.
The role of mechano growth factor in chondrocytes and cartilage defects: a concise review — Acta Biochim Biophys Sin (Shanghai), 2023 · PMID 37171185
In mechanically injured human ACL fibroblasts, MGF improved cell mobility via Rac1 and RhoA pathways.
Mechano Growth Factor Accelerates ACL Repair and Improves Cell Mobility of Mechanically Injured Human ACL Fibroblasts by Targeting Rac1-PAK1/2 and RhoA-ROCK1 Pathways — Int J Mol Sci, 2022 · PMID 35457148
Reported MGF neuroprotection against cisplatin toxicity through an interaction with nucleolin.
Mechano growth factor interacts with nucleolin to protect against cisplatin-induced neurotoxicity — Exp Neurol, 2020 · PMID 32511954
Safety signals in the literature
No human safety data. Increased IGF-IEc expression has been linked to smooth-muscle hypertrophy in fibrostenotic Crohn’s disease tissue.
Legal status (South Africa)
Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
Related compounds we stock
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Comparisons
Questions
What is MGF (Mechano Growth Factor)?
A splice variant of the IGF-1 gene (IGF-IEc) produced in response to mechanical load, with a distinct E-domain peptide studied in tissue repair. Alternative splicing of IGF-1 exons yields the IGF-IEc isoform, up-regulated by mechanical stress in muscle, bone, tendon and cartilage. Its unique E-domain peptide is studied for effects on progenitor-cell proliferation separate from mature IGF-1.
What is the research status of MGF (Mechano Growth Factor)?
Cell and animal research only; synthetic "MGF" peptides sold online are E-domain fragments with no clinical development.
What safety signals are reported for MGF (Mechano Growth Factor)?
No human safety data. Increased IGF-IEc expression has been linked to smooth-muscle hypertrophy in fibrostenotic Crohn’s disease tissue.
Does Living Water Labs stock MGF (Mechano Growth Factor)?
Not at present. MGF (Mechano Growth Factor) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not a registered medicine for human use in South Africa unless SAHPRA-registered under its own name; growth-hormone secretagogues are prohibited in sport under the WADA list. Supplied, where we stock it, strictly for laboratory research.
More in GH secretagogues
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
