Tissue-repair, gut & immune-signalling peptides
Relaxin (Serelaxin)
Also known as relaxin-2 · serelaxin · RLX
An insulin-family peptide hormone of pregnancy that remodels connective tissue, studied for anti-fibrotic and cardiovascular effects.
In 60 seconds
Recombinant serelaxin was trialled in acute heart failure; research continues in fibrosis. Systematic review data link relaxin levels to ACL-injury risk in female athletes, reflecting its collagen-loosening action.
- Reviews relaxin’s cardioprotective actions alongside its reproductive roles.
- Reviews relaxin’s anti-fibrotic effects in musculoskeletal fibrosis.
- A systematic review of relaxin and ACL-injury risk in female athletes.
Mechanism
Relaxin acts at the RXFP1 receptor, increasing matrix-metalloproteinase activity and reducing collagen deposition — the basis of its ligament-relaxing role in pregnancy and its anti-fibrotic research.
Research status
Recombinant serelaxin was trialled in acute heart failure; research continues in fibrosis. Not an approved medicine.
Key studies
Reviews relaxin’s cardioprotective actions alongside its reproductive roles.
Cardioprotective actions of relaxin — Mol Cell Endocrinol, 2019 · PMID 30625345
Reviews relaxin’s anti-fibrotic effects in musculoskeletal fibrosis.
Relaxin as a treatment for musculoskeletal fibrosis: What we know and future directions — Biochem Pharmacol, 2024 · PMID 38729446
A systematic review of relaxin and ACL-injury risk in female athletes.
Menstrual Cycle Hormone Relaxin and ACL Injuries in Female Athletes: A Systematic Review — Iowa Orthop J, 2024 · PMID 38919370
An early review describing relaxin as an insulin-like polypeptide hormone of pregnancy.
Relaxin--a review — Aust N Z J Obstet Gynaecol, 1981 · PMID 6280666
Safety signals in the literature
Systematic review data link relaxin levels to ACL-injury risk in female athletes, reflecting its collagen-loosening action.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
Related compounds we stock
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Comparisons
Questions
What is Relaxin (Serelaxin)?
An insulin-family peptide hormone of pregnancy that remodels connective tissue, studied for anti-fibrotic and cardiovascular effects. Relaxin acts at the RXFP1 receptor, increasing matrix-metalloproteinase activity and reducing collagen deposition — the basis of its ligament-relaxing role in pregnancy and its anti-fibrotic research.
What is the research status of Relaxin (Serelaxin)?
Recombinant serelaxin was trialled in acute heart failure; research continues in fibrosis. Not an approved medicine.
What safety signals are reported for Relaxin (Serelaxin)?
Systematic review data link relaxin levels to ACL-injury risk in female athletes, reflecting its collagen-loosening action.
Does Living Water Labs stock Relaxin (Serelaxin)?
Not at present. Relaxin (Serelaxin) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Repair & immune
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
