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ARA-290 research peptide

Research Overview

ARA-290

pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (cibinetide)

CoA on requestPurity CoAResearch use only

In 60 seconds

ARA-290 (cibinetide) is an 11-amino-acid peptide modelled on the helix-B surface of erythropoietin.

  • A 28-day phase 2b randomised trial of 64 subjects measured corneal nerve fibre abundance with cibinetide.
  • Describes the innate repair receptor (EPOR/CD131) and the rationale for targeting it in neuropathy.
  • In a kidney ischaemia–reperfusion model, ARA290 attenuated injury without EPO’s haematopoietic effect.

OVERVIEW

ARA-290 (pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (cibinetide)) is a research-grade peptide supplied by Living Water Labs for laboratory investigation. Cibinetide, a non-erythropoietic EPO-derived peptide — 10 mg lyophilised powder per vial.. Each published certificate is an independent Janoshik Analytical report naming the compound and its HPLC purity; certificates not yet published can be requested. The summary below outlines documented mechanisms and study areas reported in the research literature.

Scientific name

pGlu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser (cibinetide)

Molecular weight

1257.3 g/mol

Vial size

10mg

DOCUMENTED RESEARCH AREAS

  • ▸11-amino-acid peptide modelled on erythropoietin’s helix B
  • ▸Targets the innate repair receptor (EPOR / CD131 heteromer)
  • ▸Tissue-protective signalling without EPO’s red-cell effects in models
  • ▸Phase 2 trials in small-fibre neuropathy
  • ▸10 mg lyophilised vial — laboratory research use only

MECHANISM OF ACTION

ARA-290 (cibinetide) is an 11-amino-acid peptide modelled on the helix-B surface of erythropoietin. It targets the innate repair receptor, a heteromer of the EPO receptor and the β-common receptor (CD131), switching on anti-inflammatory and tissue-protective signalling while avoiding EPO’s haematopoietic effects.

  • ▸Modelled on erythropoietin’s helix-B surface
  • ▸Targets the EPOR/CD131 innate repair receptor
  • ▸No red-cell (haematopoietic) stimulation in models

STUDY SUMMARIES

3 peer-reviewed references

Invest Ophthalmol Vis Sci · 2017

Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain

A 28-day phase 2b randomised trial of 64 subjects measured corneal nerve fibre abundance with cibinetide.

View on PubMed (PMID 28475703)

Pain Rep · 2016

Targeting the innate repair receptor to treat neuropathy

Describes the innate repair receptor (EPOR/CD131) and the rationale for targeting it in neuropathy.

View on PubMed (PMID 29392190)

J Transl Med · 2013

ARA290, a non-erythropoietic EPO derivative, attenuates renal ischemia/reperfusion injury

In a kidney ischaemia–reperfusion model, ARA290 attenuated injury without EPO’s haematopoietic effect.

View on PubMed (PMID 23302512)

CITATIONS

  1. 1.Cibinetide Improves Corneal Nerve Fiber Abundance in Patients With Sarcoidosis-Associated Small Nerve Fiber Loss and Neuropathic Pain. Invest Ophthalmol Vis Sci. 2017. PMID 28475703. pubmed.ncbi.nlm.nih.gov/28475703
  2. 2.Targeting the innate repair receptor to treat neuropathy. Pain Rep. 2016. PMID 29392190. pubmed.ncbi.nlm.nih.gov/29392190
  3. 3.ARA290, a non-erythropoietic EPO derivative, attenuates renal ischemia/reperfusion injury. J Transl Med. 2013. PMID 23302512. pubmed.ncbi.nlm.nih.gov/23302512

Citations describe findings reported in the referenced preclinical, in-vitro or clinical literature. They are provided for research and educational purposes only and are not a therapeutic claim.

All information is provided for research and educational purposes only and describes findings in preclinical/in-vitro literature. Not medical advice. Products are supplied strictly for research purposes — not for human consumption.

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