Proc Natl Acad Sci U S A · 1977
Characterization of a delta-electroencephalogram (-sleep)-inducing peptide
The isolation paper: a peptide enhancing delta EEG after brain infusion in rabbits, with its amino-acid sequence.
View on PubMed (PMID 265572)◂ RESEARCH LIBRARY
Research Overview
DSIP
WAGGDASGE (emideltide)
CoA on requestPurity CoAResearch use only
In 60 seconds
Delta sleep-inducing peptide (DSIP) is a nonapeptide isolated in 1977 from rabbit cerebral venous blood and named for enhancing slow-wave (delta) EEG activity after brain infusion.
- The isolation paper: a peptide enhancing delta EEG after brain infusion in rabbits, with its amino-acid sequence.
- Double-blind studies in insomniacs examined single and repeated DSIP doses on night sleep and waking function.
- Concludes that DSIP’s link to sleep was never further characterised and its receptor remains unknown.
OVERVIEW
DSIP (WAGGDASGE (emideltide)) is a research-grade peptide supplied by Living Water Labs for laboratory investigation. Delta sleep-inducing peptide, a nonapeptide — 5 mg lyophilised powder per vial.. Each published certificate is an independent Janoshik Analytical report naming the compound and its HPLC purity; certificates not yet published can be requested. The summary below outlines documented mechanisms and study areas reported in the research literature.
Scientific name
WAGGDASGE (emideltide)
Molecular weight
848.8 g/mol
Vial size
5mg
DOCUMENTED RESEARCH AREAS
- ▸Nonapeptide isolated in 1977 during sleep research in rabbits
- ▸Named for enhancing slow-wave (delta) EEG activity after brain infusion
- ▸Examined in small human sleep studies in the 1980s
- ▸Receptor and gene still unidentified — an open research question
- ▸5 mg lyophilised vial — laboratory research use only
MECHANISM OF ACTION
Delta sleep-inducing peptide (DSIP) is a nonapeptide isolated in 1977 from rabbit cerebral venous blood and named for enhancing slow-wave (delta) EEG activity after brain infusion. Its receptor and gene have never been identified, and its link to sleep has not been firmly established.
- ▸Nonapeptide: Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu
- ▸Enhanced delta EEG activity after brain infusion in rabbits
- ▸Receptor and gene still unidentified
STUDY SUMMARIES
4 peer-reviewed referencesEur Neurol · 1986
DSIP in sleep disturbances
Double-blind studies in insomniacs examined single and repeated DSIP doses on night sleep and waking function.
View on PubMed (PMID 3758119)J Neurochem · 2006
Delta sleep-inducing peptide (DSIP): a still unresolved riddle
Concludes that DSIP’s link to sleep was never further characterised and its receptor remains unknown.
View on PubMed (PMID 16539679)Neurosci Biobehav Rev · 1984
Delta-sleep-inducing peptide (DSIP): a review
An early review of DSIP isolation, characterisation and sleep/extra-sleep effects.
View on PubMed (PMID 6145137)CITATIONS
- 1.Characterization of a delta-electroencephalogram (-sleep)-inducing peptide. Proc Natl Acad Sci U S A. 1977. PMID 265572. pubmed.ncbi.nlm.nih.gov/265572
- 2.DSIP in sleep disturbances. Eur Neurol. 1986. PMID 3758119. pubmed.ncbi.nlm.nih.gov/3758119
- 3.Delta sleep-inducing peptide (DSIP): a still unresolved riddle. J Neurochem. 2006. PMID 16539679. pubmed.ncbi.nlm.nih.gov/16539679
- 4.Delta-sleep-inducing peptide (DSIP): a review. Neurosci Biobehav Rev. 1984. PMID 6145137. pubmed.ncbi.nlm.nih.gov/6145137
Citations describe findings reported in the referenced preclinical, in-vitro or clinical literature. They are provided for research and educational purposes only and are not a therapeutic claim.
All information is provided for research and educational purposes only and describes findings in preclinical/in-vitro literature. Not medical advice. Products are supplied strictly for research purposes — not for human consumption.
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Certificate of Analysis (CoA)
Third-party lab documentation confirming a batch’s identity and purity.
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High-performance liquid chromatography — the assay behind the purity figure on every published certificate.
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Dissolving a lyophilised peptide in bacteriostatic water to a target concentration.
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Freeze-dried to a stable powder for cold, dark, long-term storage.
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Sterile water with 0.9% benzyl alcohol, used to reconstitute peptides.
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Supplied strictly for laboratory research — not for human consumption.
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