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Epitalon research peptide

Research Overview

Epitalon

Telomerase Bioregulator Research

CoA on requestPurity CoAResearch use only

In 60 seconds

Epitalon (epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modelled on the pineal peptide epithalamin.

  • In cultured human somatic cells, epithalon induced telomerase activity and elongation of telomeres.
  • Epithalon was reported to help cultured human cells overcome the Hayflick division limit in vitro.
  • An experimental study of how regulatory peptides including epitalon influence gene transcription.

OVERVIEW

Epitalon (Telomerase Bioregulator Research) is a research-grade peptide supplied by Living Water Labs for laboratory investigation. Synthetic tetrapeptide (Ala-Glu-Asp-Gly), 10 mg lyophilised powder per vial.. Each published certificate is an independent Janoshik Analytical report naming the compound and its HPLC purity; certificates not yet published can be requested. The summary below outlines documented mechanisms and study areas reported in the research literature.

Scientific name

Ala-Glu-Asp-Gly (Tetrapeptide)

Molecular weight

390.3 g/mol

Vial size

10mg

DOCUMENTED RESEARCH AREAS

  • ▸Proposed activation of telomerase to elongate telomeres in somatic cell research
  • ▸Normalises pineal function and restores circadian melatonin rhythms in animal models
  • ▸Demonstrates antioxidant activity, reducing lipid peroxidation in aging tissue
  • ▸Oncostatic effects observed in carcinogen-treated aging animal populations
  • ▸Supports neuroendocrine balance across the pineal-hypothalamic axis
  • ▸Improves markers of immune function in aging research subjects
  • ▸Short, stable tetrapeptide widely used as a longevity research model

MECHANISM OF ACTION

Epitalon (epithalon) is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) modelled on the pineal peptide epithalamin. In-vitro and animal research reports that it can activate telomerase and influence gene transcription, and it is studied as a peptide bioregulator in ageing research.

  • ▸Reported to induce telomerase activity and telomere elongation in cultured human cells
  • ▸Studied as a pineal peptide bioregulator of gene transcription
  • ▸Investigated for antioxidant and circadian effects in animal models

STUDY SUMMARIES

4 peer-reviewed references

Bull Exp Biol Med · 2003

Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells

In cultured human somatic cells, epithalon induced telomerase activity and elongation of telomeres.

View on PubMed (PMID 12937682)

Bull Exp Biol Med · 2004

Peptide promotes overcoming of the division limit in human somatic cell

Epithalon was reported to help cultured human cells overcome the Hayflick division limit in vitro.

View on PubMed (PMID 15455129)

Bull Exp Biol Med · 2003

Effect of regulatory peptides on gene transcription

An experimental study of how regulatory peptides including epitalon influence gene transcription.

View on PubMed (PMID 14666197)

Int J Mol Sci · 2025

Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties

A 2025 review summarising the bioactivity and proposed mechanisms of the pineal tetrapeptide epitalon.

View on PubMed (PMID 40141333)

CITATIONS

  1. 1.Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003. PMID 12937682. pubmed.ncbi.nlm.nih.gov/12937682
  2. 2.Peptide promotes overcoming of the division limit in human somatic cell. Bull Exp Biol Med. 2004. PMID 15455129. pubmed.ncbi.nlm.nih.gov/15455129
  3. 3.Effect of regulatory peptides on gene transcription. Bull Exp Biol Med. 2003. PMID 14666197. pubmed.ncbi.nlm.nih.gov/14666197
  4. 4.Overview of Epitalon-Highly Bioactive Pineal Tetrapeptide with Promising Properties. Int J Mol Sci. 2025. PMID 40141333. pubmed.ncbi.nlm.nih.gov/40141333

Citations describe findings reported in the referenced preclinical, in-vitro or clinical literature. They are provided for research and educational purposes only and are not a therapeutic claim.

Research synergies · compounds that fit together

Epitalon + Pinealon

Both come from the Khavinson short-peptide bioregulator programme. Epitalon is studied for telomerase activity in cell models; Pinealon for cell viability under oxidative stress. Researchers group them because they share an origin and a theory of short peptides acting on gene expression, which is the basis of the Cerebral Bioregulator stack.

Studied separately · complementary mechanismsPMID 12937682PMID 21978084PMID 14666197See the stack →

Also studied for · secondary research findings

  • EpitalonEpitalon belongs to a family of short peptides studied for directly influencing gene transcription. PMID 14666197

Reported research findings, mostly from cell and animal models. Not health claims; for research use only.

Related compounds: Short peptide bioregulators in the compound encyclopedia.

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All information is provided for research and educational purposes only and describes findings in preclinical/in-vitro literature. Not medical advice. Products are supplied strictly for research purposes — not for human consumption.

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