J Nutr · 2004
Glutathione metabolism and its implications for health
A review of glutathione metabolism and its central role in antioxidant defence and detoxification.
View on PubMed (PMID 14988435)◂ RESEARCH LIBRARY
Research Overview
Glutathione
Antioxidant Tripeptide Research
CoA on requestPurity CoAResearch use only
In 60 seconds
Glutathione is the body’s principal endogenous antioxidant — a tripeptide (gamma-glutamyl-cysteinyl-glycine) that neutralises reactive oxygen species and supports phase-II detoxification and cellular redox balance.
- A review of glutathione metabolism and its central role in antioxidant defence and detoxification.
- A randomised controlled trial reporting that sustained oral glutathione supplementation raised body glutathione stores.
- A pilot trial reporting that oral liposomal glutathione elevated glutathione stores and some markers of immune function.
OVERVIEW
Glutathione (Antioxidant Tripeptide Research) is a research-grade peptide supplied by Living Water Labs for laboratory investigation. Endogenous tripeptide (γ-Glu-Cys-Gly), 1500 mg lyophilised powder per vial.. Each published certificate is an independent Janoshik Analytical report naming the compound and its HPLC purity; certificates not yet published can be requested. The summary below outlines documented mechanisms and study areas reported in the research literature.
Scientific name
γ-L-Glutamyl-L-cysteinylglycine
Molecular weight
307.3 g/mol
Vial size
1500mg
DOCUMENTED RESEARCH AREAS
- ▸Primary intracellular antioxidant neutralising reactive oxygen species in redox research
- ▸Maintains the GSH:GSSG ratio used as a core marker of cellular redox state
- ▸Cofactor for glutathione peroxidase and glutathione-S-transferase detoxification enzymes
- ▸Regenerates oxidised vitamins C and E, sustaining antioxidant network capacity
- ▸Supports hepatic detoxification and conjugation pathway research
- ▸Modulates immune-cell redox signalling and inflammatory balance
- ▸Studied for tyrosinase inhibition in dermatological depigmentation models
MECHANISM OF ACTION
Glutathione is the body’s principal endogenous antioxidant — a tripeptide (gamma-glutamyl-cysteinyl-glycine) that neutralises reactive oxygen species and supports phase-II detoxification and cellular redox balance. Research examines its metabolism and whether supplementation can raise the body’s glutathione stores.
- ▸Primary intracellular antioxidant and redox buffer
- ▸Cofactor for glutathione-peroxidase and detoxification enzymes
- ▸Studied for whether oral/liposomal forms raise body glutathione stores
STUDY SUMMARIES
4 peer-reviewed referencesEur J Nutr · 2015
Randomized controlled trial of oral glutathione supplementation on body stores of glutathione
A randomised controlled trial reporting that sustained oral glutathione supplementation raised body glutathione stores.
View on PubMed (PMID 24791752)Eur J Clin Nutr · 2018
Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function
A pilot trial reporting that oral liposomal glutathione elevated glutathione stores and some markers of immune function.
View on PubMed (PMID 28853742)Integr Med (Encinitas) · 2014
Glutathione!
A concise clinical overview of glutathione physiological roles and research interest.
View on PubMed (PMID 26770075)CITATIONS
- 1.Glutathione metabolism and its implications for health. J Nutr. 2004. PMID 14988435. pubmed.ncbi.nlm.nih.gov/14988435
- 2.Randomized controlled trial of oral glutathione supplementation on body stores of glutathione. Eur J Nutr. 2015. PMID 24791752. pubmed.ncbi.nlm.nih.gov/24791752
- 3.Oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function. Eur J Clin Nutr. 2018. PMID 28853742. pubmed.ncbi.nlm.nih.gov/28853742
- 4.Glutathione!. Integr Med (Encinitas). 2014. PMID 26770075. pubmed.ncbi.nlm.nih.gov/26770075
Citations describe findings reported in the referenced preclinical, in-vitro or clinical literature. They are provided for research and educational purposes only and are not a therapeutic claim.
Research synergies · compounds that fit together
Glutathionethe cell’s main antioxidant
NAD+redox coenzyme
Both sides of cellular redox
Glutathione + NAD+
Glutathione is the most abundant antioxidant inside cells and keeps oxidative damage in check. NAD+ is a redox coenzyme at the centre of energy metabolism. Researchers study them together because oxidative stress and falling NAD+ are two linked features of cellular ageing. This is the Vitality stack.
Also studied for · secondary research findings
- GlutathioneA human study reported that liposomal glutathione taken by mouth raised the body’s glutathione stores. PMID 28853742
Reported research findings, mostly from cell and animal models. Not health claims; for research use only.
Related compounds: Mitochondrial & longevity research compounds in the compound encyclopedia.
All information is provided for research and educational purposes only and describes findings in preclinical/in-vitro literature. Not medical advice. Products are supplied strictly for research purposes — not for human consumption.
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GUIDES & TOOLS
How-To Research Guides
Step-by-step guides — reconstitution, dosing, storage, handling and CoAs.
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Work out exact bacteriostatic-water volumes for any vial — a free lab tool.
Explore →Compound Research Library
Per-compound overviews: documented mechanisms, study areas and cited literature.
Explore →Purity CoAs
Independent Janoshik Analytical certificates — compound identity and HPLC purity — published as styled summaries, the rest on request.
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Purity, CoAs, storage, shipping and ordering — answered.
Explore →PEPTIDE GLOSSARY
Certificate of Analysis (CoA)
Third-party lab documentation confirming a batch’s identity and purity.
Explore →HPLC Verification
High-performance liquid chromatography — the assay behind the purity figure on every published certificate.
Explore →Reconstitution
Dissolving a lyophilised peptide in bacteriostatic water to a target concentration.
Explore →Lyophilised
Freeze-dried to a stable powder for cold, dark, long-term storage.
Explore →Bacteriostatic Water
Sterile water with 0.9% benzyl alcohol, used to reconstitute peptides.
Explore →Research Use Only
Supplied strictly for laboratory research — not for human consumption.
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