Drugs · 2019
Bremelanotide: First Approval
Summarises the development and 2019 US approval of bremelanotide as a melanocortin receptor agonist for HSDD.
View on PubMed (PMID 31429064)◂ RESEARCH LIBRARY
Research Overview
PT-141
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (bremelanotide)
CoA on requestPurity CoAResearch use only
In 60 seconds
PT-141 (bremelanotide) is a cyclic heptapeptide melanocortin-receptor agonist derived from melanotan II.
- Summarises the development and 2019 US approval of bremelanotide as a melanocortin receptor agonist for HSDD.
- A development profile of PT-141 as a nasal spray investigated for erectile and female sexual dysfunction.
- Reviews central melanocortin-system pharmacology, the receptor family PT-141 acts on.
OVERVIEW
PT-141 (Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (bremelanotide)) is a research-grade peptide supplied by Living Water Labs for laboratory investigation. Bremelanotide, a cyclic melanocortin-receptor agonist — 10 mg lyophilised powder per vial.. Each published certificate is an independent Janoshik Analytical report naming the compound and its HPLC purity; certificates not yet published can be requested. The summary below outlines documented mechanisms and study areas reported in the research literature.
Scientific name
Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-OH (bremelanotide)
Molecular weight
1025.2 g/mol
Vial size
10mg
DOCUMENTED RESEARCH AREAS
- ▸Cyclic melanocortin-receptor agonist derived from melanotan II
- ▸Acts mainly at central MC4 receptors in receptor-pharmacology studies
- ▸A reference ligand in central melanocortin-system research
- ▸Bremelanotide received US approval in 2019 in an injectable form
- ▸10 mg lyophilised vial — laboratory research use only
MECHANISM OF ACTION
PT-141 (bremelanotide) is a cyclic heptapeptide melanocortin-receptor agonist derived from melanotan II. It acts mainly at the MC4 receptor (and MC1R) in the central nervous system, on central pathways rather than on blood flow. It received US approval in 2019 for a specific female indication and is used as a reference ligand in central melanocortin-system research.
- ▸Cyclic melanocortin-receptor agonist derived from melanotan II
- ▸Acts mainly at central MC4 receptors
- ▸Acts on central pathways rather than on blood flow
STUDY SUMMARIES
3 peer-reviewed referencesCurr Opin Investig Drugs · 2004
PT-141 Palatin
A development profile of PT-141 as a nasal spray investigated for erectile and female sexual dysfunction.
View on PubMed (PMID 15134289)Nat Rev Endocrinol · 2023
Targeting the central melanocortin system for the treatment of metabolic disorders
Reviews central melanocortin-system pharmacology, the receptor family PT-141 acts on.
View on PubMed (PMID 37365323)CITATIONS
- 1.Bremelanotide: First Approval. Drugs. 2019. PMID 31429064. pubmed.ncbi.nlm.nih.gov/31429064
- 2.PT-141 Palatin. Curr Opin Investig Drugs. 2004. PMID 15134289. pubmed.ncbi.nlm.nih.gov/15134289
- 3.Targeting the central melanocortin system for the treatment of metabolic disorders. Nat Rev Endocrinol. 2023. PMID 37365323. pubmed.ncbi.nlm.nih.gov/37365323
Citations describe findings reported in the referenced preclinical, in-vitro or clinical literature. They are provided for research and educational purposes only and are not a therapeutic claim.
All information is provided for research and educational purposes only and describes findings in preclinical/in-vitro literature. Not medical advice. Products are supplied strictly for research purposes — not for human consumption.
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Independent Janoshik Analytical certificates — compound identity and HPLC purity — published as styled summaries, the rest on request.
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Purity, CoAs, storage, shipping and ordering — answered.
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Certificate of Analysis (CoA)
Third-party lab documentation confirming a batch’s identity and purity.
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High-performance liquid chromatography — the assay behind the purity figure on every published certificate.
Explore →Reconstitution
Dissolving a lyophilised peptide in bacteriostatic water to a target concentration.
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Freeze-dried to a stable powder for cold, dark, long-term storage.
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Sterile water with 0.9% benzyl alcohol, used to reconstitute peptides.
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Supplied strictly for laboratory research — not for human consumption.
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