Tissue-repair, gut & immune-signalling peptides
VIP (Vasoactive Intestinal Peptide)
Also known as vasoactive intestinal polypeptide · aviptadil
A 28-amino-acid neuropeptide of the secretin/glucagon family with vasodilatory, secretory and immune-modulating actions.
In 60 seconds
Research peptide; an inhaled/intravenous form (aviptadil) has been trialled in respiratory failure, with mixed results. Systemic VIP lowers blood pressure and can cause flushing and diarrhoea — the VIPoma syndrome illustrates excess VIP physiology.
- Reviews VIP/PACAP receptor biology in CNS and inflammatory disorders.
- In models, VIP promoted intestinal secretory-cell differentiation and reduced radiation injury.
- Studied VIP-loaded nanoparticles for immune modulation and stem-cell support in tendon repair models.
Mechanism
VIP acts through VPAC1 and VPAC2 receptors (shared with PACAP). It relaxes smooth muscle, stimulates intestinal secretion, regulates immune-cell function and is studied as a neuroprotective and anti-inflammatory signal.
Research status
Research peptide; an inhaled/intravenous form (aviptadil) has been trialled in respiratory failure, with mixed results. VIP-secreting tumours (VIPomas) are a separate clinical topic.
Key studies
Reviews VIP/PACAP receptor biology in CNS and inflammatory disorders.
Pituitary adenylate cyclase-activating polypeptide/vasoactive intestinal peptide (Part 2): biology and clinical importance in central nervous system and inflammatory disorders — Curr Opin Endocrinol Diabetes Obes, 2021 · PMID 33481421
In models, VIP promoted intestinal secretory-cell differentiation and reduced radiation injury.
Vasoactive intestinal peptide promotes secretory differentiation and mitigates radiation-induced intestinal injury — Stem Cell Res Ther, 2024 · PMID 39380035
Studied VIP-loaded nanoparticles for immune modulation and stem-cell support in tendon repair models.
Nanoparticle-Driven Tendon Repair: Role of Vasoactive Intestinal Peptide in Immune Modulation and Stem Cell Enhancement — ACS Nano, 2025 · PMID 40184556
Reviews VIPomas, whose excess VIP causes a watery-diarrhoea syndrome.
Vasoactive Intestinal Peptide-Secreting Tumors: A Review — Pancreas, 2019 · PMID 31609932
Safety signals in the literature
Systemic VIP lowers blood pressure and can cause flushing and diarrhoea — the VIPoma syndrome illustrates excess VIP physiology.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
Related compounds we stock
Now in the catalogue
VIP (Vasoactive Intestinal Peptide) is now in our catalogue as a research vial. Pre-orders are 10% off until the 15 October delivery lands.
Comparisons
Questions
What is VIP (Vasoactive Intestinal Peptide)?
A 28-amino-acid neuropeptide of the secretin/glucagon family with vasodilatory, secretory and immune-modulating actions. VIP acts through VPAC1 and VPAC2 receptors (shared with PACAP). It relaxes smooth muscle, stimulates intestinal secretion, regulates immune-cell function and is studied as a neuroprotective and anti-inflammatory signal.
What is the research status of VIP (Vasoactive Intestinal Peptide)?
Research peptide; an inhaled/intravenous form (aviptadil) has been trialled in respiratory failure, with mixed results. VIP-secreting tumours (VIPomas) are a separate clinical topic.
What safety signals are reported for VIP (Vasoactive Intestinal Peptide)?
Systemic VIP lowers blood pressure and can cause flushing and diarrhoea — the VIPoma syndrome illustrates excess VIP physiology.
Does Living Water Labs stock VIP (Vasoactive Intestinal Peptide)?
Not at present. VIP (Vasoactive Intestinal Peptide) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Repair & immune
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
