Nootropic & neuropeptide research compounds
Alpha-GPC (Choline Alfoscerate)
Also known as choline alfoscerate · L-α-glycerylphosphorylcholine · α-GPC
A choline-containing phospholipid and acetylcholine precursor used as a medicine or nutraceutical for cognition.
In 60 seconds
Prescription medicine in some countries (cognitive decline) and a supplement elsewhere; a 2023 meta-analysis covers adult-onset cognitive dysfunction. Generally well tolerated in trials.
- A meta-analysis of choline alfoscerate in adult-onset cognitive dysfunction.
- A randomised trial measured acute cognitive performance with alpha-GPC in healthy men.
- Reviews preclinical and clinical evidence for choline supplement forms including alfoscerate.
Mechanism
Alpha-GPC delivers choline to the brain for acetylcholine synthesis and membrane phospholipids; animal work reports increased hippocampal neurogenesis.
Research status
Prescription medicine in some countries (cognitive decline) and a supplement elsewhere; a 2023 meta-analysis covers adult-onset cognitive dysfunction.
Key studies
A meta-analysis of choline alfoscerate in adult-onset cognitive dysfunction.
Activity of Choline Alphoscerate on Adult-Onset Cognitive Dysfunctions: A Systematic Review and Meta-Analysis — J Alzheimers Dis, 2023 · PMID 36683513
A randomised trial measured acute cognitive performance with alpha-GPC in healthy men.
Acute Alpha-Glycerylphosphorylcholine Supplementation Enhances Cognitive Performance in Healthy Men — Nutrients, 2024 · PMID 39683633
Reviews preclinical and clinical evidence for choline supplement forms including alfoscerate.
Choline supplements: An update — Front Endocrinol (Lausanne), 2023 · PMID 36950691
In rats, alpha-GPC after seizures increased hippocampal neurogenesis and was neuroprotective.
Late treatment with choline alfoscerate (l-alpha glycerylphosphorylcholine, α-GPC) increases hippocampal neurogenesis and provides protection against seizure-induced neuronal death and cognitive impairment — Brain Res, 2017 · PMID 27765578
Safety signals in the literature
Generally well tolerated in trials.
Legal status (South Africa)
Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
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Comparisons
Questions
What is Alpha-GPC (Choline Alfoscerate)?
A choline-containing phospholipid and acetylcholine precursor used as a medicine or nutraceutical for cognition. Alpha-GPC delivers choline to the brain for acetylcholine synthesis and membrane phospholipids; animal work reports increased hippocampal neurogenesis.
What is the research status of Alpha-GPC (Choline Alfoscerate)?
Prescription medicine in some countries (cognitive decline) and a supplement elsewhere; a 2023 meta-analysis covers adult-onset cognitive dysfunction.
What safety signals are reported for Alpha-GPC (Choline Alfoscerate)?
Generally well tolerated in trials.
Does Living Water Labs stock Alpha-GPC (Choline Alfoscerate)?
Not at present. Alpha-GPC (Choline Alfoscerate) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered as a medicine for human use in South Africa (unless stated otherwise); research use only.
More in Nootropic & neuro
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
