Short peptide bioregulators
Cortagen (Ala-Glu-Asp-Pro)
Also known as AEDP · Ala-Glu-Asp-Pro
A synthetic tetrapeptide bioregulator modelled on brain-cortex peptide extracts (Cortexin), studied in nerve-regeneration and brain-ischaemia models.
In 60 seconds
Animal and cell research from one research school; no clinical trials outside Russia. No independent human safety data.
- In rats after sciatic-nerve transection, cortagen increased regenerating-fibre growth rate and conduction velocity.
- Cortagen, Epithalon, Livagen and Vilon each stimulated growth of explants from their matching tissue in organotypic culture.
- In rats with chronic brain ischaemia, cortexin and cortagen accelerated behavioural recovery.
Mechanism
Reported to stimulate growth of cortical explants tissue-specifically and to influence oxidative processes and nerve regeneration; proposed to act via gene-expression regulation like other Khavinson peptides.
Research status
Animal and cell research from one research school; no clinical trials outside Russia.
Key studies
In rats after sciatic-nerve transection, cortagen increased regenerating-fibre growth rate and conduction velocity.
Effect of tetrapeptide cortagen on regeneration of sciatic nerve — Bull Exp Biol Med, 2000 · PMID 11276314
Cortagen, Epithalon, Livagen and Vilon each stimulated growth of explants from their matching tissue in organotypic culture.
Tissue-specific effects of peptides — Bull Exp Biol Med, 2001 · PMID 11713572
In rats with chronic brain ischaemia, cortexin and cortagen accelerated behavioural recovery.
[Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia] — Eksp Klin Farmakol, 2011 · PMID 21476278
Epithalon and cortagen reduced lipid-peroxidation products and protein oxidation in rats.
Effects of bioactive tetrapeptides on free-radical processes — Bull Exp Biol Med, 2007 · PMID 18239817
Safety signals in the literature
No independent human safety data.
Legal status (South Africa)
Not registered medicines in South Africa; research use only.
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Comparisons
Questions
What is Cortagen (Ala-Glu-Asp-Pro)?
A synthetic tetrapeptide bioregulator modelled on brain-cortex peptide extracts (Cortexin), studied in nerve-regeneration and brain-ischaemia models. Reported to stimulate growth of cortical explants tissue-specifically and to influence oxidative processes and nerve regeneration; proposed to act via gene-expression regulation like other Khavinson peptides.
What is the research status of Cortagen (Ala-Glu-Asp-Pro)?
Animal and cell research from one research school; no clinical trials outside Russia.
What safety signals are reported for Cortagen (Ala-Glu-Asp-Pro)?
No independent human safety data.
Does Living Water Labs stock Cortagen (Ala-Glu-Asp-Pro)?
Not at present. Cortagen (Ala-Glu-Asp-Pro) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered medicines in South Africa; research use only.
More in Bioregulators
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
