Short peptide bioregulators
Vilon (Lys-Glu)
Also known as KE dipeptide · Lys-Glu
A synthetic dipeptide (Lys-Glu) from the Khavinson bioregulator programme, studied for immune and chromatin effects in cell and animal models.
In 60 seconds
Cell and animal studies, almost all from one research group; no independent clinical trials. No independent human safety data.
- In lymphocytes from older people, Vilon was reported to unroll condensed (heterochromatic) chromatin in vitro.
- Microarray analysis of mouse heart found expression changes in about 2% of clones after Vilon or Epithalon.
- Vilon, Epithalon and Cortagen activated IL-2 mRNA synthesis in mouse splenocytes in vitro.
Mechanism
Its developers report that Vilon "deheterochromatinises" aged chromatin in cultured lymphocytes and modulates gene expression (including in heart tissue and splenocyte IL-2), effects attributed to direct DNA/chromatin interaction of short peptides.
Research status
Cell and animal studies, almost all from one research group; no independent clinical trials.
Key studies
In lymphocytes from older people, Vilon was reported to unroll condensed (heterochromatic) chromatin in vitro.
Bioregulator Vilon-induced reactivation of chromatin in cultured lymphocytes from old people — Biogerontology, 2004 · PMID 15105581
Microarray analysis of mouse heart found expression changes in about 2% of clones after Vilon or Epithalon.
Studies of the effects of Vilon and Epithalon on gene expression in mouse heart using DNA-microarray technology — Bull Exp Biol Med, 2002 · PMID 12360356
Vilon, Epithalon and Cortagen activated IL-2 mRNA synthesis in mouse splenocytes in vitro.
In vitro effect of short peptides on expression of interleukin-2 gene in splenocytes — Bull Exp Biol Med, 2002 · PMID 12447482
Safety signals in the literature
No independent human safety data.
Legal status (South Africa)
Not registered medicines in South Africa; research use only.
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Comparisons
Questions
What is Vilon (Lys-Glu)?
A synthetic dipeptide (Lys-Glu) from the Khavinson bioregulator programme, studied for immune and chromatin effects in cell and animal models. Its developers report that Vilon "deheterochromatinises" aged chromatin in cultured lymphocytes and modulates gene expression (including in heart tissue and splenocyte IL-2), effects attributed to direct DNA/chromatin interaction of short peptides.
What is the research status of Vilon (Lys-Glu)?
Cell and animal studies, almost all from one research group; no independent clinical trials.
What safety signals are reported for Vilon (Lys-Glu)?
No independent human safety data.
Does Living Water Labs stock Vilon (Lys-Glu)?
Not at present. Vilon (Lys-Glu) is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered medicines in South Africa; research use only.
More in Bioregulators
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
