Short peptide bioregulators
Thymalin
Also known as thymus polypeptide complex · KE dipeptide
A polypeptide extract of calf thymus used as an immunomodulatory drug in Russia; its active short peptides (e.g. Lys-Glu) are studied as bioregulators.
In 60 seconds
Registered in Russia; outside that, evidence is largely from one research school and published mostly in Russian-language or niche journals. Long clinical use in Russia is reported by its developers; independent safety data are limited.
- Reported that thymalin activated differentiation of human haematopoietic stem cells in vitro.
- Studied how the KE and EW dipeptides in thymalin affect expression of genes linked to COVID-19 pathogenesis.
- Reports the developers’ clinical assessment of thymalin and epithalamin as geroprotectors.
Mechanism
Thymalin is described as restoring T-cell function and differentiation. Research from the St Petersburg bioregulation group attributes activity to short dipeptides (KE, EW) that influence gene expression in immune cells.
Research status
Registered in Russia; outside that, evidence is largely from one research school and published mostly in Russian-language or niche journals.
Key studies
Reported that thymalin activated differentiation of human haematopoietic stem cells in vitro.
Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells — Bull Exp Biol Med, 2020 · PMID 33237528
Studied how the KE and EW dipeptides in thymalin affect expression of genes linked to COVID-19 pathogenesis.
The Influence of KE and EW Dipeptides in the Composition of the Thymalin Drug on Gene Expression and Protein Synthesis Involved in the Pathogenesis of COVID-19 — Int J Mol Sci, 2023 · PMID 37686182
Reports the developers’ clinical assessment of thymalin and epithalamin as geroprotectors.
[Geroprotective effect of thymalin and epithalamin] — Adv Gerontol, 2002 · PMID 12577695
Safety signals in the literature
Long clinical use in Russia is reported by its developers; independent safety data are limited.
Legal status (South Africa)
Not registered medicines in South Africa; research use only.
Related compounds we stock
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Comparisons
Questions
What is Thymalin?
A polypeptide extract of calf thymus used as an immunomodulatory drug in Russia; its active short peptides (e.g. Lys-Glu) are studied as bioregulators. Thymalin is described as restoring T-cell function and differentiation. Research from the St Petersburg bioregulation group attributes activity to short dipeptides (KE, EW) that influence gene expression in immune cells.
What is the research status of Thymalin?
Registered in Russia; outside that, evidence is largely from one research school and published mostly in Russian-language or niche journals.
What safety signals are reported for Thymalin?
Long clinical use in Russia is reported by its developers; independent safety data are limited.
Does Living Water Labs stock Thymalin?
Not at present. Thymalin is profiled here for reference, with citations to the published literature. You can ask to be notified if we add it. Not registered medicines in South Africa; research use only.
More in Bioregulators
Research reference only. This page summarises published literature; it is not medical advice and contains no guidance on human use. Products supplied by Living Water Labs are for laboratory research only.
