Cortagen vs Pinealon
Both are synthetic bioregulators studied for the nervous system. Cortagen (Ala-Glu-Asp-Pro) was modelled on cortex extract; pinealon (Glu-Asp-Arg) on pineal and brain tissue.
Cortagen
A synthetic tetrapeptide bioregulator modelled on brain-cortex peptide extracts (Cortexin), studied in nerve-regeneration and brain-ischaemia models.
BEST STUDIED FOR
Bioregulators
Read the cited profile →
Pinealon
Pinealon is a synthetic tripeptide (Glu-Asp-Arg, "EDR") among the Khavinson peptide bioregulators.
BEST STUDIED FOR
Neuronal-protection models
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Side by side · to buy
Price, purity and dispatch
| Compare | Cortagen | Pinealon10mg |
|---|---|---|
| Price | — | R429 |
| Cost per mg | — | R42.9 / mg |
| Purity (Janoshik) | — | On request |
| Stock | — | Restocking |
| Dispatch | — | When restocked |
| Certificate | — | Request CoA |
| Literature | — | 2 papers → |
| Research focus | Bioregulators | Neuronal-protection models |
| Read the cited profile | Notify me |
Prices are read live from the catalogue. Cost per mg is the vial price over its stated mg. Purity is shown only where the certificate is published. Every compound is supplied for laboratory research only.
SIDE BY SIDE
| Cortagen | Pinealon | |
|---|---|---|
| The key difference | Cortex-associated tetrapeptide | Brain-associated tripeptide |
| Class | Bioregulators | Bioregulators |
| Mechanism | Reported to stimulate growth of cortical explants tissue-specifically and to influence oxidative processes and nerve regeneration; proposed to act via gene-expression regulation like other Khavinson peptides. | Pinealon is a synthetic tripeptide (Glu-Asp-Arg, "EDR") among the Khavinson peptide bioregulators. |
| Status | Animal and cell research from one research school; no clinical trials outside Russia. | A synthetic tripeptide bioregulator; not an approved medicine. |
| Reported safety signals | No independent human safety data. | No controlled human safety data; findings are from cell and animal models. |
| A key study | In rats after sciatic-nerve transection, cortagen increased regenerating-fibre growth rate and conduction velocity. (Bull Exp Biol Med 2000, PMID 11276314) | In cell studies, Pinealon increased cell viability by suppressing free-radical levels and activating proliferation. (Rejuvenation Res 2011, PMID 21978084) |
WHEN TO RESEARCH WHICH
Both are preclinical; the choice follows the tissue model. Both are discussed here strictly as research compounds; nothing on this page is medical advice or a dosing guide.
REFERENCES (PUBMED)
- [Cortagen] Effect of tetrapeptide cortagen on regeneration of sciatic nerve — Bull Exp Biol Med 2000. PMID 11276314
- [Cortagen] Tissue-specific effects of peptides — Bull Exp Biol Med 2001. PMID 11713572
- [Cortagen] [Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia] — Eksp Klin Farmakol 2011. PMID 21476278
- [Pinealon] Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes — Rejuvenation Res 2011. PMID 21978084
- [Pinealon] EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease — Molecules 2020. PMID 33396470
FREQUENTLY ASKED
What is the difference between Cortagen and Pinealon?
Both are synthetic bioregulators studied for the nervous system. Cortagen (Ala-Glu-Asp-Pro) was modelled on cortex extract; pinealon (Glu-Asp-Arg) on pineal and brain tissue.
What is the regulatory status of Cortagen and Pinealon?
Cortagen: Animal and cell research from one research school; no clinical trials outside Russia. Pinealon: A synthetic tripeptide bioregulator; not an approved medicine.
What safety signals have been reported?
Cortagen: No independent human safety data. Pinealon: No controlled human safety data; findings are from cell and animal models.
Which studies is this comparison based on?
For Cortagen: “Effect of tetrapeptide cortagen on regeneration of sciatic nerve” (PMID 11276314); “Tissue-specific effects of peptides” (PMID 11713572); “[Cortexin and cortagen as correcting agents in functional and metabolic disorders in the brain in chronic ischemia]” (PMID 21476278). For Pinealon: “Pinealon increases cell viability by suppression of free radical levels and activating proliferative processes” (PMID 21978084); “EDR Peptide: Possible Mechanism of Gene Expression and Protein Synthesis Regulation Involved in the Pathogenesis of Alzheimer’s Disease” (PMID 33396470).
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